FAM21C and VPS35

Number of citations of the paper that reports this interaction (PMID 20923837)
36

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		FAM21C	VPS35
Gene Name		family with sequence similarity 21, member C	vacuolar protein sorting 35 homolog (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Early Endosome Membrane WASH Complex	Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Retromer Complex Extracellular Vesicular Exosome Tubular Endosome
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Protein Transporter Activity
	Biological Process	Retrograde Transport, Endosome To Golgi Regulation Of Substrate Adhesion-dependent Cell Spreading Retrograde Transport, Endosome To Plasma Membrane Negative Regulation Of Barbed-end Actin Filament Capping	Intracellular Protein Transport Retrograde Transport, Endosome To Golgi Transcytosis Negative Regulation Of Late Endosome To Lysosome Transport Retrograde Transport, Endosome To Plasma Membrane
Pathways			WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978)
Protein-Protein Interactions		4 interactors: ATXN1 FKBP15 KIAA0196 VPS35	9 interactors: APP FAM21C MTNR1B SNX1 SNX3 VEGFA VPS26B VPS29 ZNF512B
Entrez ID		253725	55737
HPRD ID		11094	06085
Ensembl ID		ENSG00000172661
Uniprot IDs		A8K5W5 B3KMC4 Q9Y4E1	Q96QK1
PDB IDs			2R17
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Late Endosome To Lysosome Transport Endosomal Transport Intracellular Transport Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Retrograde Transport, Endosome To Plasma Membrane Transport Transcytosis Establishment Of Localization In Cell Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Localization	Retrograde Transport, Endosome To Golgi Vesicle-mediated Transport Endosomal Transport Establishment Of Localization In Cell Cellular Localization Intracellular Transport Retrograde Transport, Endosome To Plasma Membrane Regulation Of Cell Development Platelet Degranulation Positive Regulation Of Protein Kinase D Signaling Basophil Chemotaxis Intralumenal Vesicle Formation Transport Positive Regulation Of Protein Localization To Early Endosome Synaptic Growth At Neuromuscular Junction Negative Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Retinal Ganglion Cell Axon Guidance Coronary Vein Morphogenesis Primitive Erythrocyte Differentiation VEGF-activated Neuropilin Signaling Pathway Regulation Of Receptor Activity Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Barbed-end Actin Filament Capping Collateral Sprouting In Absence Of Injury Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Deacetylase Activity Protein Transport Cell Maturation Establishment Of Protein Localization Positive Regulation Of Lymphangiogenesis Cardiac Vascular Smooth Muscle Cell Development Positive Regulation Of Mast Cell Chemotaxis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Differentiation Lamellipodium Morphogenesis Collateral Sprouting Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Axon Midline Choice Point Recognition Regulation Of Histone Deacetylase Activity Regulation Of Neurogenesis Regulation Of Endocytosis Positive Regulation Of Deacetylase Activity Coronary Artery Morphogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Platelet Activation Regulation Of Cell-substrate Adhesion
Tagcloud ?			allosteric biophysical cargo consists deciphered disrupts endosomal endosomes fret golgi gtpase hela insights instrumental nexins perturbed rab7 recognizing recruit recruitment recruits recycle retromer snx sorting sub vacuolar vps26
Tagcloud (Difference) ?			allosteric biophysical cargo consists deciphered disrupts endosomal endosomes fret golgi gtpase hela insights instrumental nexins perturbed rab7 recognizing recruit recruitment recruits recycle retromer snx sorting sub vacuolar vps26
Tagcloud (Intersection) ?