WASHC2C and WASHC5

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical, affinity chromatography technology, two hybrid)

		WASHC2C	WASHC5
Description		WASH complex subunit 2C	WASH complex subunit 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Endosome Early Endosome Cytosol Plasma Membrane Membrane Early Endosome Membrane WASH Complex	Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Cytosol Early Endosome Membrane Neuronal Cell Body WASH Complex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Phosphate Binding Retromer Complex Binding	Protein Binding
	Biological Process	Protein Transport Endosomal Transport Endocytic Recycling Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Barbed-end Actin Filament Capping	Oocyte Maturation Endosome Organization Lysosome Organization Positive Regulation Of Neuron Projection Development Protein Transport Endosomal Transport Actin Filament Polymerization Protein-containing Complex Localization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Polar Body Extrusion After Meiotic Divisions Protein-containing Complex Organization Regulation Of Actin Nucleation Meiotic Spindle Assembly Regulation Of Vesicle Size Endosome Fission
Pathways
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS
Interacting Genes		3 interacting genes: ATXN1 SUMO2 WASHC5	2 interacting genes: WASHC1 WASHC2C
Entrez ID		253725	9897
HPRD ID		11094	13786
Ensembl ID		ENSG00000172661	ENSG00000164961
Uniprot IDs		A8K5W5 B3KMC4 Q9Y4E1	E7EQI7 Q12768
PDB IDs
Enriched GO Terms of Interacting Partners?			WASH Complex Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Endocytic Recycling Retrograde Transport, Endosome To Golgi Cytosolic Transport Vesicle-mediated Transport To The Plasma Membrane Early Endosome Membrane Negative Regulation Of Barbed-end Actin Filament Capping Regulation Of Actin Filament Organization Endosomal Transport Early Endosome Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Localization Within Membrane Phosphatidylinositol 3-kinase Inhibitor Activity Retromer Complex Binding Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Protein Localization To Endosome Endosome Exocyst Positive Regulation Of Protein Depolymerization Arp2/3 Complex-mediated Actin Nucleation Phosphatidylinositol-5-phosphate Binding Actin Nucleation Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Protein Transport Gamma-tubulin Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein-containing Complex Disassembly Vesicle-mediated Transport Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Organelle Organization Intracellular Transport Alpha-tubulin Binding Phosphatidylinositol-3-phosphate Binding Establishment Of Protein Localization Positive Regulation Of Actin Filament Polymerization Extracellular Matrix Disassembly Regulation Of Actin Filament Depolymerization Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Localization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?