FAM21C and KIAA0196

Number of citations of the paper that reports this interaction (PMID 20923837)
36

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		FAM21C	KIAA0196
Gene Name		family with sequence similarity 21, member C	KIAA0196
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Early Endosome Membrane WASH Complex	Early Endosome Endoplasmic Reticulum Cytosol WASH Complex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding
	Biological Process	Retrograde Transport, Endosome To Golgi Regulation Of Substrate Adhesion-dependent Cell Spreading Retrograde Transport, Endosome To Plasma Membrane Negative Regulation Of Barbed-end Actin Filament Capping	Endosomal Transport
Pathways
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978)	Response to statin therapy ( 20339536)
Protein-Protein Interactions		4 interactors: ATXN1 FKBP15 KIAA0196 VPS35	2 interactors: FAM21C WASH1
Entrez ID		253725	9897
HPRD ID		11094	13786
Ensembl ID		ENSG00000172661	ENSG00000164961
Uniprot IDs		A8K5W5 B3KMC4 Q9Y4E1	E7EQI7 Q12768
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Late Endosome To Lysosome Transport Endosomal Transport Intracellular Transport Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Retrograde Transport, Endosome To Plasma Membrane Transport Transcytosis Establishment Of Localization In Cell Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Localization	Retrograde Transport, Endosome To Plasma Membrane Retrograde Transport, Endosome To Golgi Endosomal Transport Negative Regulation Of Barbed-end Actin Filament Capping Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Pseudopodium Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Arp2/3 Complex-mediated Actin Nucleation Vesicle-mediated Transport Intracellular Transport Actin Nucleation Regulation Of Cellular Component Organization Establishment Of Localization In Cell Extracellular Matrix Disassembly Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Assembly Positive Regulation Of Protein Polymerization Cellular Localization Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Regulation Of Cell-substrate Adhesion Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length
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