FRZB and PNO1

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		FRZB	PNO1
Name		frizzled related protein	partner of NOB1 homolog
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Membrane	Nucleus Nucleoplasm Nucleolus Cytosol Small-subunit Processome
	Molecular Function	Protein Binding Wnt-protein Binding	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Skeletal System Development Epithelial Cell Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Development Neural Crest Cell Differentiation Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Non-canonical Wnt Signaling Pathway Inner Ear Morphogenesis Positive Regulation Of Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Negative Regulation Of Cartilage Development Somite Development Hepatocyte Differentiation Negative Regulation Of Hepatocyte Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis	Ribosomal Small Subunit Biogenesis
Pathways		None	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
GWAS		Blood protein levels ( 30072576 ) Heel bone mineral density ( 28869591 30598549 ) Neurological blood protein biomarker levels ( 31320639 ) Night sleep phenotypes ( 27126917 ) Waist-to-hip circumference ratio (dietary energy interaction) ( 23192594 ) Working memory ( 31598132 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: BMP10
Interacting Genes		8 interacting genes: BBS10 CYSRT1 EHF ELF5 PNO1 POLA2 RBX1 SMAD1	10 interacting genes: ATP5F1C FRZB GSTP1 IGFBP5 KLF6 PDPK1 PICK1 RXRG SGSM2 SUPT5H
Entrez ID		2487	56902
HPRD ID		07282	14250
Ensembl ID		ENSG00000162998	ENSG00000115946
Uniprot IDs		D9ZGF6 Q92765	Q9NRX1
PDB IDs		Not available	6G18 6G4S 6G4W 6G51 6G53 6G5I 6ZUO 6ZXD 6ZXE 7MQ8 7MQ9 7MQA 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 8ZDC 8ZDD
GO Terms Enriched among Interactors		Cell Fate Commitment Involved In Formation Of Primary Germ Layer	Cellular Developmental Process Negative Regulation Of Hepatocyte Differentiation Negative Regulation Of Growth Cell Development Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Proliferation Dinitrosyl-iron Complex Binding S-nitrosoglutathione Binding Response To Epidermal Growth Factor Nitric Oxide Storage Negative Regulation Of Muscle Hypertrophy Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Skeletal Muscle Hypertrophy 3-phosphoinositide-dependent Protein Kinase Activity Glial Cell Development Regulation Of Cartilage Development Regulation Of Smooth Muscle Cell Migration Response To Peptide Hormone Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion TRAF2-GSTP1 Complex DSIF Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Response To Insulin Stimulus Regulation Of Cell Growth Insulin-like Growth Factor Binding Protein Complex Regulation Of Cell Population Proliferation Regulation Of Cell Migration Glutathione Derivative Biosynthetic Process Cellular Response To Cell-matrix Adhesion Insulin-like Growth Factor Ternary Complex Membrane Curvature Sensor Activity Epithelial Cell Development Convergent Extension Involved In Organogenesis Regulation Of Cell Motility Negative Regulation Of Smooth Muscle Cell Chemotaxis Nitric Oxide Binding Response To L-ascorbic Acid Mammary Gland Involution Positive Regulation Of Sarcomere Organization