FRZB and BBS10

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		FRZB	BBS10
Gene Name		frizzled-related protein	Bardet-Biedl syndrome 10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Membrane Integral Component Of Membrane	Cilium
	Molecular Function	G-protein Coupled Receptor Activity Wnt-protein Binding Wnt-activated Receptor Activity	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding ATP Binding
	Biological Process	Skeletal System Development Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Development Neural Crest Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Convergent Extension Involved In Organogenesis Negative Regulation Of Cartilage Development Somite Development Negative Regulation Of Hepatocyte Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis	Retina Homeostasis Visual Perception Nonmotile Primary Cilium Assembly Regulation Of Protein Complex Assembly Cellular Protein Metabolic Process Photoreceptor Cell Maintenance Response To Stimulus Chaperone-mediated Protein Complex Assembly
Pathways			Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		7 interactors: BBS10 EHF ELF5 PNO1 POLA2 RBX1 SMAD1	12 interactors: CSNK1E FRZB HDAC6 MAP3K7 MAPK6 MAPK8IP2 NR4A1 PTK2 RASA1 RGS2 TNFSF11 YAE1D1
Entrez ID		2487	79738
HPRD ID		07282	08036
Ensembl ID		ENSG00000162998	ENSG00000179941
Uniprot IDs		D9ZGF6 Q92765	Q8TAM1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Cell Proliferation Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Primary MiRNA Processing Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Epithelium Development Cellular Aromatic Compound Metabolic Process Osteoblast Fate Commitment Cellular Nitrogen Compound Metabolic Process Protein Neddylation SMAD Protein Complex Assembly Cellular Protein Complex Assembly Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Homeostatic Process Chaperone-mediated Protein Complex Assembly Mesodermal Cell Fate Commitment Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cardiac Muscle Cell Proliferation Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Cellular Biosynthetic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To BMP Stimulus Mammary Gland Epithelial Cell Differentiation Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Macromolecule Biosynthetic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Ectoderm Development Tissue Development Nonmotile Primary Cilium Assembly Mesodermal Cell Differentiation Macromolecule Biosynthetic Process Epithelial Cell Differentiation Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Cell Fate Commitment Involved In Formation Of Primary Germ Layer Protein Import Into Nucleus, Translocation DNA Strand Elongation Cardiac Muscle Tissue Growth Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Photoreceptor Cell Maintenance DNA Replication Initiation	Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity MAPK Cascade Signal Complex Assembly Regulation Of Cellular Component Organization Signal Transduction By Phosphorylation Cell Communication JNK Cascade Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Protein Complex Assembly Regulation Of Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Cell Death Blood Vessel Morphogenesis Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Kinase Activity Signal Transduction Regulation Of Cell Shape Positive Regulation Of Kinase Activity Regulation Of JNK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Cytoskeleton Organization Blood Vessel Development Regulation Of Protein Phosphorylation Vasculature Development Phosphorylation Negative Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Signaling Positive Regulation Of Transferase Activity Negative Regulation Of Signaling Chemotaxis Response To Growth Factor Positive Regulation Of Protein Metabolic Process Regulation Of MAPK Cascade Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Difference) ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Intersection) ?