LTC4S and TMEM52B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LTC4S	TMEM52B
Description		leukotriene C4 synthase	transmembrane protein 52B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle	Membrane Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding Transferase Activity Lyase Activity Identical Protein Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Leukotriene Metabolic Process Leukotriene Biosynthetic Process Long-chain Fatty Acid Biosynthetic Process Carboxylic Acid Biosynthetic Process Cellular Oxidant Detoxification
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX) Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Drugs		Glutathione Azelastine
Diseases
GWAS
Interacting Genes		12 interacting genes: ALOX5 ALOX5AP CD79A CREB3L1 EBP FFAR3 FXYD3 GPR152 GPR42 MGST1 SLC7A14 TMEM52B	70 interacting genes: ALG3 APOD APOL2 APOL3 BET1 BTN2A2 C1GALT1 C3orf52 CLDN19 CLDN4 CNIH1 CNIH3 CRYAA CSGALNACT2 DNAJC30 EMD FXYD3 GAST GPR25 GPR37L1 IGFBP5 INSIG2 ITGAM JAGN1 LHFPL5 LPAR3 LTC4S MAL MARCHF2 MIP MS4A13 NINJ2 NRM NSG1 ORMDL1 PEDS1-UBE2V1 PGAP2 PLN PLP1 RTP2 SEC22A SERP1 SLC30A2 SLC30A8 SLC35A4 SLC35B4 SLC38A7 SMIM1 TF TMEM100 TMEM107 TMEM109 TMEM128 TMEM147 TMEM14C TMEM203 TMEM218 TMEM267 TMEM50B TMEM54 TMEM60 TMEM86B TMEM97 TMUB2 TRAM1L1 TRARG1 VAMP3 VAMP5 YIPF6 ZDHHC15
Entrez ID		4056	120939
HPRD ID		02004	08709
Ensembl ID		ENSG00000213316	ENSG00000165685
Uniprot IDs		Q16873	Q4KMG9
PDB IDs		2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4BPM 4J7T 4J7Y 4JC7 4JCZ 4JRZ 4WAB 5HV9 6R7D 9G0U 9G0V 9G14 9G1T
Enriched GO Terms of Interacting Partners?		Leukotriene Production Involved In Inflammatory Response Arachidonate Metabolite Production Involved In Inflammatory Response Membrane Production Of Molecular Mediator Involved In Inflammatory Response Leukotriene Biosynthetic Process Glutathione Peroxidase Activity Negative Regulation Of Sprouting Angiogenesis Glutathione Transferase Activity Leukotriene Metabolic Process Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Nuclear Envelope Negative Regulation Of Response To Endoplasmic Reticulum Stress Icosanoid Biosynthetic Process Endoplasmic Reticulum Membrane Cellular Response To Lipid Hydroperoxide Cholesterol-5,6-oxide Hydrolase Activity Regulation Of Sprouting Angiogenesis Nuclear Membrane Leukotriene A4 Metabolic Process Arachidonate 8(S)-lipoxygenase Activity Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus C-8 Sterol Isomerase Activity Cholestenol Delta-isomerase Activity Cellular Oxidant Detoxification Regulation Of Response To Endoplasmic Reticulum Stress Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell IgM B Cell Receptor Complex Response To Lipid Hydroperoxide Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Steroid Delta-isomerase Activity Extracellular Matrix Constituent Secretion Icosanoid Metabolic Process G Protein-coupled Receptor Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Cellular Detoxification B Cell Receptor Complex Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Endoplasmic Reticulum Leukotriene-C4 Synthase Activity Small Molecule Biosynthetic Process Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Arachidonate Binding Gamma-aminobutyric Acid Import Gamma-aminobutyric Acid Transmembrane Transporter Activity	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Membrane Protein Binding Golgi Membrane Localization Within Membrane Establishment Of Protein Localization To Plasma Membrane Cellular Localization Protein Insertion Into Membrane Establishment Of Protein Localization Zinc:proton Antiporter Activity Nuclear Outer Membrane Protein Localization To Membrane Paracellular Transport Protein Localization To Postsynapse Lipid Binding SNAP Receptor Activity Transmembrane Transport Structural Constituent Of Myelin Sheath Zinc Ion Import Into Organelle Intestinal Epithelial Cell Development Pyrimidine Nucleotide-sugar Transmembrane Transport Vesicle-mediated Transport
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