LTC4S and ALOX5

Number of citations of the paper that reports this interaction (PMID 19233132)
1

Data Source:
BioGRID (fluorescent resonance energy transfer)

		LTC4S	ALOX5
Gene Name		leukotriene C4 synthase	arachidonate 5-lipoxygenase
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Extracellular Space Nuclear Envelope Nuclear Envelope Lumen Cytosol Nuclear Matrix Nuclear Membrane
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding	Arachidonate 5-lipoxygenase Activity Iron Ion Binding Protein Binding
	Biological Process	Leukotriene Metabolic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Oxidation-reduction Process Lipoxin Metabolic Process	Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Small Molecule Metabolic Process Oxidation-reduction Process Lipoxin Metabolic Process
Pathways		Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of Leukotrienes (LT) and Eoxins (EX)	Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of Leukotrienes (LT) and Eoxins (EX)
Drugs		Glutathione	Vitamin E Masoprocol Aminosalicylic Acid Mesalazine Montelukast Diclofenac Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Heme
Diseases
GWAS			Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978)
Protein-Protein Interactions		3 interactors: ALOX5 ALOX5AP MGST1	17 interactors: ACTB ALOX5AP APP CEP57L1 CEP63 COTL1 DICER1 GRB2 HHIPL2 LTC4S MAD1L1 MAPKAPK2 MEOX1 NUTM1 REL SYCE1 TGFBRAP1
Entrez ID		4056	240
HPRD ID		02004	01065
Ensembl ID		ENSG00000213316	ENSG00000012779
Uniprot IDs		Q16873	E5FPY5 E5FPY8 P09917
PDB IDs		2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV	2ABV 3O8Y 3V92 3V98 3V99
Enriched GO Terms of Interacting Partners?		Lipoxin Metabolic Process Lipoxygenase Pathway Protein Homotrimerization Leukotriene Biosynthetic Process Protein Trimerization Leukotriene Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Cellular Response To Lipid Hydroperoxide Leukotriene Production Involved In Inflammatory Response Protein Homooligomerization Response To Lipid Hydroperoxide Fatty Acid Metabolic Process Protein Oligomerization Small Molecule Metabolic Process Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Hydroperoxide Leydig Cell Differentiation Response To Hydroperoxide Glutathione Derivative Biosynthetic Process Production Of Molecular Mediator Involved In Inflammatory Response Cellular Lipid Metabolic Process Protein Complex Assembly Carboxylic Acid Metabolic Process Cellular Response To Calcium Ion Organic Acid Metabolic Process Lipid Metabolic Process Biosynthetic Process Glutathione Metabolic Process Oxidation-reduction Process Response To Calcium Ion Cellular Response To Metal Ion Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Cellular Response To Inorganic Substance Cellular Component Assembly Response To Xenobiotic Stimulus Peptide Metabolic Process Male Gonad Development Male Sex Differentiation Cellular Response To Oxidative Stress Gonad Development Development Of Primary Sexual Characteristics Cellular Modified Amino Acid Metabolic Process	Leukotriene Metabolic Process Lipoxin Metabolic Process Arachidonic Acid Metabolic Process Defense Response Lipoxygenase Pathway Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Leukotriene Biosynthetic Process Cellular Component Assembly MRNA Stabilization Innate Immune Response Cell Division Immune System Process Platelet Activation Cell Cycle Process Cell Cycle Checkpoint Icosanoid Biosynthetic Process Wound Healing Regulation Of MRNA Stability Unsaturated Fatty Acid Biosynthetic Process Regulation Of RNA Stability Neuron Projection Morphogenesis Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Regulation Of Metaphase Plate Congression Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Positive Regulation Of Metabolic Process Response To External Stimulus Endocytosis Response To Stress Response To Wounding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Fatty Acid Metabolic Process Immune Response Microtubule-based Process Regulation Of ERBB Signaling Pathway Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation Synaptic Growth At Neuromuscular Junction Zygote Asymmetric Cell Division Spindle Assembly Cell Cycle Neuron Projection Development Signal Transduction In Response To DNA Damage Cell Projection Morphogenesis Vesicle-mediated Transport Targeting Of MRNA For Destruction Involved In RNA Interference Collateral Sprouting In Absence Of Injury Axon Guidance
Tagcloud ?		apcdd1 attributable beadchip clec2d dox doxycycline efnb1 il1rn illumina interrogate ocil ogn opg osteoblast osteoclastogenesis osteoclastogenic paid pluripotent profiled rspo2 runx2 rx2 sema3a sema7a slco2b1 splenocytes st2 tnc tnfrsf11b	af4 calcitriol conversely deacetylase derivatives deriving elongation encodes hdac hdac1 hdaci inactive lineage lipoxygenase mll overwrites physiologically portion relieving smad3 smad4 surprisingly switch transcriptionally transforming trichostatin trimethylation tsa
Tagcloud (Difference) ?		apcdd1 attributable beadchip clec2d dox doxycycline efnb1 il1rn illumina interrogate ocil ogn opg osteoblast osteoclastogenesis osteoclastogenic paid pluripotent profiled rspo2 runx2 rx2 sema3a sema7a slco2b1 splenocytes st2 tnc tnfrsf11b	af4 calcitriol conversely deacetylase derivatives deriving elongation encodes hdac hdac1 hdaci inactive lineage lipoxygenase mll overwrites physiologically portion relieving smad3 smad4 surprisingly switch transcriptionally transforming trichostatin trimethylation tsa
Tagcloud (Intersection) ?