HSD17B1

Description		hydroxysteroid 17-beta dehydrogenase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Catalytic Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Steroid Binding Protein Binding Oxidoreductase Activity Small Molecule Binding Protein Homodimerization Activity Testosterone Dehydrogenase (NAD+) Activity Testosterone Dehydrogenase (NADP+) Activity NADP Binding NADP+ Binding 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Estradiol Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Lysosome Organization Skeletal Muscle Tissue Development Estrogen Metabolic Process Gene Expression Bone Development Adipose Tissue Development Testosterone Biosynthetic Process Cellular Response To Metal Ion
Pathways		Estrogen biosynthesis The canonical retinoid cycle in rods (twilight vision)
Drugs		NADH Androstenedione Androstanedione Equilin EM-1745 Stanolone Nicotinamide adenine dinucleotide phosphate Stanolone acetate
Diseases
GWAS		Eczema ( 31361310) Parkinson's disease ( 27182965) Pulse pressure ( 28135244 30578418)
Interacting Genes		2 interacting genes: ALOX5 PTEN
Entrez ID		3292
HPRD ID		00185
Ensembl ID		ENSG00000108786
Uniprot IDs		A0A0A0MQS7 P14061
PDB IDs		1A27 1BHS 1DHT 1EQU 1FDS 1FDT 1FDU 1FDV 1FDW 1I5R 1IOL 1JTV 1QYV 1QYW 1QYX 3DEY 3DHE 3HB4 3HB5 3KLM 3KLP 3KM0 6CGC 6CGE 6DTP 6MNC 6MNE 7X3Z
Enriched GO Terms of Interacting Partners?		Lipid Modification Regulation Of Wound Healing Regulation Of Response To Wounding Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Negative Regulation Of Wound Healing Negative Regulation Of Synaptic Vesicle Clustering Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Arachidonate 8(S)-lipoxygenase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Arachidonate Metabolite Production Involved In Inflammatory Response Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Vascular Wound Healing Negative Regulation Of Peptidyl-serine Phosphorylation Postsynaptic Density Assembly Lipid Biosynthetic Process Leukocyte Chemotaxis Involved In Inflammatory Response Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Anaphase-promoting Complex Binding Forebrain Morphogenesis Presynaptic Membrane Assembly Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Lipoxygenase Pathway Regulation Of Inflammatory Response To Wounding Nuclear Envelope Lumen Production Of Molecular Mediator Involved In Inflammatory Response Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Postsynaptic Specialization Assembly Maternal Behavior Presynaptic Membrane Organization
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