MTCH2 and GLP1R

Number of citations of the paper that reports this interaction (PubMedID 26272612)
67

Data Source:
BioGRID (protein complementation assay)

		MTCH2	GLP1R
Description		mitochondrial carrier 2	glucagon like peptide 1 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Membrane Insertase Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Signaling Receptor Activity Glucagon-like Peptide 1 Receptor Activity
	Biological Process	Lactate Metabolic Process Mitochondrial Transport Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Membrane Potential Hematopoietic Stem Cell Migration Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Outer Membrane Negative Regulation Of Glycolytic Process Lipid Homeostasis Hematopoietic Stem Cell Homeostasis Protein Localization To Mitochondrion Cellular Response To Radiation Establishment Of Protein Localization To Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Hepatocyte Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Stem Cell Differentiation	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Hormone Secretion Regulation Of Biological Quality Cellular Response To Glucagon Stimulus Response To Psychosocial Stress
Pathways			Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors
Drugs			Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide Taspoglutide Tirzepatide Efpeglenatide Glutazumab
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bitter beverage consumption ( 31046077) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 20935630 29381148 29273807 28892062 28448500 26961502 19079261 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Fruit consumption ( 32066663) General cognitive ability ( 29844566) Haemorrhoidal disease ( 33888516) Hypertension ( 31879980) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mood instability ( 31168069) Neuroticism ( 29255261) Pulse pressure ( 27841878) Refractive error ( 32231278) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 27841878) Walking pace ( 33128006)	Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282) Fasting glucose ( 34059833) Type 2 diabetes ( 32499647)
Interacting Genes		5 interacting genes: APOC1 ATP5MJ ESR1 GLP1R XRN1	112 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ARLN ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSRT1 CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP5-9 LAPTM4A LINC00269 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NBPF19 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SLC61A1 SLC9D1 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99
Entrez ID		23788	2740
HPRD ID		14788	00677
Ensembl ID		ENSG00000109919	ENSG00000112164
Uniprot IDs		B4DHQ0 E9PIE4 Q9Y6C9	A0A142FHB8 P43220
PDB IDs			3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1 6ORV 6VCB 6X18 6X19 6X1A 6XOX 7C2E 7DUQ 7DUR 7E14 7EVM 7FIM 7KI0 7KI1 7LCI 7LCJ 7LCK 7LLL 7LLY 7RG9 7RGP 7RTB 7S15 7S1M 7S3I 7VBH 7VBI 7X8R 7X8S 8JIP 8JIR 8JIS 8WG7 8YW3 9IVG 9IVM 9J1P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Glucagon-like Peptide 1 Receptor Activity Cellular Response To Puromycin Cellular Response To Cycloheximide Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Very-low-density Lipoprotein Particle Clearance Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Regulation Of Phosphatidylcholine Catabolic Process Nuclear Estrogen Receptor Activity Regulation Of Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of Cytosolic Calcium Ion Concentration TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Response To Psychosocial Stress Glucagon Receptor Activity Response To Cycloheximide 5'-3' RNA Exonuclease Activity Positive Regulation Of Free Ubiquitin Chain Polymerization Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Triglyceride Catabolic Process Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Cellular Response To Oxygen-containing Compound Regulation Of Nitric-oxide Synthase Activity Response To Mitochondrial Depolarisation Steroid Metabolic Process Nitric-oxide Synthase Regulator Activity Post-translational Protein Targeting To Membrane, Translocation G-quadruplex RNA Binding Phospholipase Inhibitor Activity G-quadruplex DNA Binding Regulation Of Phosphatidylcholine Metabolic Process Prostate Gland Growth Vagina Development 5'-3' Exonuclease Activity Very-low-density Lipoprotein Particle Assembly Estrogen Response Element Binding Cellular Response To Glucagon Stimulus Nuclear MRNA Surveillance Branching Involved In Prostate Gland Morphogenesis Chylomicron Phospholipid Efflux Branch Elongation Of An Epithelium	Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Intermediate Filament Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Keratin Filament Neutrophil Migration Host-mediated Activation Of Viral Process Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Intracellular Chemical Homeostasis Synaptic Vesicle Membrane Intracellular Calcium Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Granulocyte Migration
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