PANX1 and WFDC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PANX1	WFDC2
Description		pannexin 1	WAP four-disulfide core domain 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Bleb Protein-containing Complex	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Protease Binding Actin Binding Signaling Receptor Binding Structural Molecule Activity Gap Junction Channel Activity Monoatomic Anion Channel Activity Calcium Channel Activity ATP Transmembrane Transporter Activity Protein Binding Channel Activity Wide Pore Channel Activity Leak Channel Activity Identical Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Response To Ischemia Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Cell-cell Signaling ATP Transport Cell Differentiation Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Response To ATP Monoatomic Ion Transmembrane Transport Oogenesis Positive Regulation Of Macrophage Cytokine Production Calcium Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport	Proteolysis Spermatogenesis Antibacterial Humoral Response Innate Immune Response
Pathways		Electric Transmission Across Gap Junctions The NLRP3 inflammasome High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Formation of the nephric duct
Drugs		Probenecid
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301 34315874) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010 33339817 33547301 34315874) Autoimmune thyroid disease ( 32581359) Liver enzyme levels (alanine transaminase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Squamous cell lung carcinoma ( 28604730)	Brain structure ( 20171287)
Interacting Genes		16 interacting genes: APOA2 APOL2 AQP2 BCL2L2 BUD31 CFHR5 CLCA4 FAXDC2 FDFT1 GNAS P2RX7 SLC38A7 TMEM229B TNF VAMP5 WFDC2	15 interacting genes: ARL13B CD79A COQ9 CPLX4 CREB3L1 CYB5R3 FAM209A FKBP7 GORAB LMNA PANX1 PTN SLC22A23 STOM TMX2
Entrez ID		24145	10406
HPRD ID		10526	11684
Ensembl ID		ENSG00000110218	ENSG00000101443
Uniprot IDs		Q96RD7	A0A384MTN6 Q14508
PDB IDs		6LTN 6LTO 6M02 6M66 6M67 6M68 6V6D 6WBF 6WBG 6WBI 6WBK 6WBL 6WBM 6WBN 7DWB 7F8J 7F8N 7F8O 7WSV 8GTS 8GTT 8GYO
Enriched GO Terms of Interacting Partners?		Sterol Metabolic Process Channel Activity High-density Lipoprotein Particle Binding Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Lipid Catabolic Process Renal Water Homeostasis Disordered Domain Specific Binding Extrinsic Apoptotic Signaling Pathway Multicellular Organismal-level Water Homeostasis Lipoprotein Metabolic Process Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Cytokine Production Involved In Immune Response Sterol Biosynthetic Process Squalene Synthase [NAD(P)H] Activity Response To Fluid Shear Stress Response To Bacterium Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Positive Regulation Of Phagocytosis Peptidyl-methionine Modification Regulation Of Lipid Catabolic Process Cellular Response To Amyloid-beta Alcohol Metabolic Process Extracellular Region High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Catabolic Process Response To Amyloid-beta Lipid Biosynthetic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cholesterol Import Lumenal Side Of Membrane Response To Stress Cellular Response To Mercury Ion Cellular Response To Water Deprivation Multicellular Organismal-level Chemical Homeostasis Glycerol Transmembrane Transporter Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mu-type Opioid Receptor Binding Regulation Of Protein Secretion Positive Regulation Of Bleb Assembly Positive Regulation Of Interleukin-1 Production Regulation Of Amine Transport
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