PANX1

Gene Name		pannexin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Integral Component Of Membrane Bleb Protein Complex
	Molecular Function	Protease Binding Receptor Binding Calcium Channel Activity Leak Channel Activity Ion Channel Binding Protein Heterodimerization Activity Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding
	Biological Process	Response To Ischemia Cation Transport Calcium Ion Transport Synaptic Transmission Response To ATP Protein Hexamerization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Calcium Ion Transmembrane Transport
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Transmission across Electrical Synapses Electric Transmission Across Gap Junctions Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: GNAS P2RX7
Entrez ID		24145
HPRD ID		10526
Ensembl ID		ENSG00000110218
Uniprot IDs		Q96RD7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ossification Tissue Homeostasis Regulation Of Ossification Post-embryonic Body Morphogenesis Multicellular Organismal Homeostasis Skeletal System Morphogenesis Phospholipid Transfer To Membrane NAD Transport Homotypic Cell-cell Adhesion Positive Regulation Of Interleukin-1 Alpha Secretion Regulation Of Protein Secretion Positive Regulation Of Cytolysis Multicellular Organismal Protein Catabolic Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Glutamate Secretion Multicellular Organismal Protein Metabolic Process Positive Regulation Of Interleukin-1 Alpha Production Secretion By Cell Response To Drug Single Organismal Cell-cell Adhesion Positive Regulation Of Gamma-aminobutyric Acid Secretion Skeletal System Development Regulation Of Protein Transport Secretion Regulation Of Secretion Regulation Of Killing Of Cells Of Other Organism Bleb Assembly Positive Regulation Of Mitochondrial Depolarization Regulation Of Establishment Of Protein Localization Cell Activation Positive Regulation Of Amino Acid Transport Pore Complex Assembly Negative Regulation Of Bone Resorption Regulation Of Glutamate Secretion Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Response To Parathyroid Hormone Phagolysosome Assembly Regulation Of Protein Localization Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Bone Remodeling Positive Regulation Of Prostaglandin Secretion Sensory Perception Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Response To Lipid Adrenergic Receptor Signaling Pathway Chemical Homeostasis Negative Regulation Of Tissue Remodeling Response To Organic Cyclic Compound
Tagcloud ?		afferent apical arteries arterioles atp channels collecting conduit connexin descending ducts efferent electrolyte freshly limbs lumen mechanosensitive multifaceted participate purinergic reabsorption released stimulates thin tubular tubules ubiquitously vasculature