BRD1 and H3F3A

Number of citations of the paper that reports this interaction (PMID 21880731)
9

Data Source:
BioGRID (pull down)

		BRD1	H3F3A
Gene Name		bromodomain containing 1	H3 histone, family 3A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm MOZ/MORF Histone Acetyltransferase Complex	Nuclear Chromosome Nuclear Nucleosome Extracellular Region Nucleus Nucleoplasm Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Zinc Ion Binding Histone Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Histone H3 Acetylation	Chromatin Silencing At RDNA DNA Replication-independent Nucleosome Assembly Blood Coagulation Gene Expression Positive Regulation Of Cell Growth DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Cellular Senescence Signaling by Wnt M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Natriuretic peptide levels ( 21273288) Schizophrenia ( 23894747)
Protein-Protein Interactions		9 interactors: FEZ1 FEZ2 H2AFX H3F3A HIST2H3C KIAA1377 SS18L1 VIM ZNF512B	25 interactors: ASF1A ASF1B BPTF BRD1 CABIN1 CARM1 CBX3 CHD1 CREBBP DAXX KAT2B KMT2A MAPK9 NOS3 PARP10 SETD7 SMARCA1 SMARCA4 SMARCA5 SS18 SSRP1 SUPT16H TLE2 UHRF1 ZMYND11
Entrez ID		23774	3020
HPRD ID		06848	03082
Ensembl ID		ENSG00000100425	ENSG00000163041
Uniprot IDs		J3KNX6 O95696	B2R4P9 P84243
PDB IDs		2KU3 2L43 2LQ6 3LYI 3RCW	2L43 3ASK 3ASL 3AV2 3JVK 3MUK 3MUL 3QL9 3QLA 3QLC 4GNE 4GNF 4GNG 4GU0 4GUR 4GUS 4GY5 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4L58
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromatin Silencing At RDNA Chromatin Silencing DNA Methylation Regulation Of Neuron Projection Development Regulation Of Dendrite Morphogenesis Negative Regulation Of Gene Expression, Epigenetic DNA Modification Cell Projection Organization Regulation Of Cell Projection Organization Gene Silencing Regulation Of Dendrite Development Regulation Of Neuron Differentiation Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Generation Of Neurons Regulation Of Neurogenesis Chromatin Organization DNA Packaging Neurogenesis Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Bergmann Glial Cell Differentiation Neuron Projection Development Positive Regulation Of Neuron Projection Development Cell Development Heterocycle Metabolic Process Cell Projection Morphogenesis Cellular Aromatic Compound Metabolic Process Organelle Organization Regulation Of Cell Development Cell Part Morphogenesis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Component Organization Cellular Nitrogen Compound Metabolic Process Neuron Development DNA Conformation Change Positive Regulation Of Cell Projection Organization Gene Expression Negative Regulation Of Macroautophagy Chromosome Organization Regulation Of Metabolic Process Cell Morphogenesis DNA Metabolic Process Establishment Of Mitochondrion Localization Positive Regulation Of Neuron Differentiation	Chromatin Organization Chromatin Modification Chromosome Organization Organelle Organization Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Chromatin Remodeling Gene Expression Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleosome Organization Chromatin Assembly Or Disassembly Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process DNA Replication-independent Nucleosome Assembly Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Nucleosome Assembly Internal Protein Amino Acid Acetylation Peptidyl-lysine Modification Protein Acetylation Chromatin Assembly Negative Regulation Of Cellular Metabolic Process DNA Conformation Change Negative Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Negative Regulation Of Transcription, DNA-templated Regulation Of Cellular Process Viral Process
Tagcloud ?		acetylation acetyltransferase appearance causes cd4 cd8 chip confirms demonstrates dp dynamic enhancer enhancers h3k14 haematopoietic hat hbo1 indistinguishable insufficiency localizes machinery mark progenitors promotes responsible serves tcrbeta thymocytes variegated	36me3 atrx code combinatorial commonest daxx g34r g34v gbms global h3k h3k27me3 h3k36me3 h3k4me3 h3k9me3 highlights hist1h3b idh1 innovative k27m mark marks notably opportunity pediatric polycomb tailored trimethylation underlies
Tagcloud (Difference) ?		acetylation acetyltransferase appearance causes cd4 cd8 chip confirms demonstrates dp dynamic enhancer enhancers h3k14 haematopoietic hat hbo1 indistinguishable insufficiency localizes machinery progenitors promotes responsible serves tcrbeta thymocytes variegated	36me3 atrx code combinatorial commonest daxx g34r g34v gbms global h3k h3k27me3 h3k36me3 h3k4me3 h3k9me3 highlights hist1h3b idh1 innovative k27m marks notably opportunity pediatric polycomb tailored trimethylation underlies
Tagcloud (Intersection) ?		mark