SLC7A11 and KRTAP1-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC7A11	KRTAP1-3
Description		solute carrier family 7 member 11	keratin associated protein 1-3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Brush Border Membrane Microvillus Membrane Cell Projection Apical Part Of Cell Astrocyte Projection	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Protein Binding L-amino Acid Transmembrane Transporter Activity Cystine:glutamate Antiporter Activity Transmembrane Transporter Activity L-kynurenine Transmembrane Transporter Activity	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Amino Acid Transmembrane Transport Glutathione Metabolic Process Amino Acid Transport Brain Development Visual Learning Response To Toxic Substance L-cystine Transport L-glutamate Transmembrane Transport Ventricular System Development Striatum Development Adult Behavior Regulation Of Neutrophil Apoptotic Process Cellular Response To Stress Cellular Response To Oxidative Stress Glutathione Transmembrane Transport Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of Melanin Biosynthetic Process Lung Alveolus Development Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Organization Regulation Of Protein Transport Response To Redox State Transmembrane Transport Limb Development Platelet Aggregation Intracellular Glutamate Homeostasis L-glutamate Import Across Plasma Membrane Negative Regulation Of Ferroptosis Dipeptide Import Across Plasma Membrane L-kynurenine Transmembrane Transport Regulation Of Cellular Response To Oxidative Stress Regulation Of Cysteine Metabolic Process Regulation Of Glutathione Biosynthetic Process Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Glutamate Metabolic Process
Pathways		Basigin interactions Amino acid transport across the plasma membrane NFE2L2 regulating anti-oxidant/detoxification enzymes	Keratinization
Drugs		Cystine Glutamic acid Riluzole Sulfasalazine Acetylcysteine Thimerosal
Diseases
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Mood instability ( 31168069) Neurociticism ( 29500382) Sleep duration (> 10 hours) ( 33075057)
Interacting Genes		7 interacting genes: BAAT KRTAP1-1 KRTAP1-3 PCBP2 SLC3A2 TERT ZRANB1	183 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYP21A2 CYSRT1 DAGLB DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 EMC7 FBXW5 FZD10 GLP1R GLRX3 GLYAT GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRF1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC5A5 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZFTRAF1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837
Entrez ID		23657	81850
HPRD ID		09720	12305
Ensembl ID		ENSG00000151012	ENSG00000221880
Uniprot IDs		Q9UPY5	Q8IUG1
PDB IDs		7CCS 7EPZ 7P9U 7P9V
Enriched GO Terms of Interacting Partners?		Glycine N-choloyltransferase Activity Bile Acid Conjugation Apical Pole Of Neuron TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Medium-chain Fatty Acyl-CoA Hydrolase Activity Choloyl-CoA Hydrolase Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity Exogenous Protein Binding Amino Acid Transport Complex Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex Keratin Filament Methionine Transport L-leucine Import Across Plasma Membrane Aromatic Amino Acid Transmembrane Transporter Activity Tyrosine Transport RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA-directed DNA Polymerase Activity L-histidine Transport Phenylalanine Transport Valine Transport L-alanine Import Across Plasma Membrane Positive Regulation Of Wnt Signaling Pathway Protein K29-linked Deubiquitination Isoleucine Transport L-leucine Transmembrane Transporter Activity L-alanine Transmembrane Transport Tryptophan Transport Protein K33-linked Deubiquitination Intermediate Filament Promoter-enhancer Loop Anchoring Activity L-alanine Transmembrane Transporter Activity Positive Regulation Of Protein Localization To Nucleolus Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Viral RNA Genome Replication Telomerase Activity Establishment Of Protein Localization To Telomere L-alanine Transport SiRNA Processing N-acyltransferase Activity Thiolester Hydrolase Activity L-leucine Transport Proline Transport Nuclear Telomere Cap Complex Taurine Metabolic Process	Epidermis Development Keratinization Protein Binding Intermediate Filament Keratin Filament Tissue Development Hair Cycle Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Animal Organ Morphogenesis Negative Regulation Of Defense Response Identical Protein Binding
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