SLC7A11 and SLC3A2

Number of citations of the paper that reports this interaction (PMID 12235164)
46

Data Source:
HPRD (in vivo)

		SLC7A11	SLC3A2
Gene Name		solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	solute carrier family 3 (amino acid transporter heavy chain), member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Rough Endoplasmic Reticulum Cytoskeleton Plasma Membrane Cell Surface Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Cystine:glutamate Antiporter Activity	Double-stranded RNA Binding Catalytic Activity Calcium:sodium Antiporter Activity Protein Binding Neutral Amino Acid Transmembrane Transporter Activity Cation Binding Poly(A) RNA Binding
	Biological Process	Ion Transport Amino Acid Transport Response To Oxidative Stress Brain Development Blood Coagulation Response To Toxic Substance Response To Nicotine Leukocyte Migration Transmembrane Transport Lens Fiber Cell Differentiation Platelet Aggregation L-glutamate Transmembrane Transport	Carbohydrate Metabolic Process Ion Transport Calcium Ion Transport Amino Acid Transport Blood Coagulation Tryptophan Transport Cell Growth Sodium Ion Transmembrane Transport Response To Exogenous DsRNA Leukocyte Migration Transmembrane Transport Leucine Import
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides Amino acid transport across the plasma membrane SLC-mediated transmembrane transport Basigin interactions Cell surface interactions at the vascular wall	Transport of inorganic cations/anions and amino acids/oligopeptides Amino acid transport across the plasma membrane SLC-mediated transmembrane transport Basigin interactions Cell surface interactions at the vascular wall
Drugs		L-Cystine L-Glutamic Acid Riluzole Sulfasalazine
Diseases
GWAS
Protein-Protein Interactions		3 interactors: BAAT SLC3A2 TERT	11 interactors: EGFR FAM57A HNRNPD ICAM1 ITGB1 SLC7A10 SLC7A11 SLC7A5 SLC7A7 SLC7A8 VHL
Entrez ID		23657	6520
HPRD ID		09720	01148
Ensembl ID		ENSG00000151012	ENSG00000168003
Uniprot IDs		Q9UPY5	J3KPF3 P08195
PDB IDs			2DH2 2DH3
Enriched GO Terms of Interacting Partners?		Response To DsRNA Leucine Import Bile Acid Conjugation Negative Regulation Of Production Of SiRNA Involved In RNA Interference Tryptophan Transport Negative Regulation Of RNA Interference Transcription, RNA-templated Telomere Formation Via Telomerase Age-dependent Telomere Shortening Aromatic Amino Acid Transport Telomere Maintenance Via Telomere Shortening Carboxylic Acid Transport Organic Acid Transport Leucine Transport Telomere Assembly Taurine Metabolic Process Organic Anion Transport Branched-chain Amino Acid Transport Replicative Cell Aging Telomere Maintenance Via Telomerase Production Of SiRNA Involved In RNA Interference Amino Acid Import RNA Interference Replicative Senescence Anion Transport RNA-dependent DNA Replication Bile Acid Biosynthetic Process Regulation Of Gene Silencing DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Bile Acid And Bile Salt Transport Response To Organic Cyclic Compound Glycine Metabolic Process Cellular Response To DsRNA Bile Acid Metabolic Process Posttranscriptional Gene Silencing Neutral Amino Acid Transport Response To Exogenous DsRNA Serine Family Amino Acid Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Gene Silencing By RNA Acyl-CoA Metabolic Process Cell Aging Organ Regeneration Telomere Maintenance Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Gene Silencing Amino Acid Transmembrane Transport DNA Biosynthetic Process Steroid Biosynthetic Process	Leukocyte Migration Cell Migration Cell Motility Amino Acid Transmembrane Transport Amino Acid Transport Locomotion Neutral Amino Acid Transport Blood Coagulation Hemostasis L-alpha-amino Acid Transmembrane Transport Movement Of Cell Or Subcellular Component Regulation Of Body Fluid Levels Wound Healing Carboxylic Acid Transport Organic Acid Transport Response To Wounding Immune System Process Response To Stress Anion Transmembrane Transport Organic Anion Transport Anion Transport Cell Adhesion Mediated By Integrin Single Organismal Cell-cell Adhesion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Vasoconstriction Ion Transmembrane Transport Response To Gonadotropin Cell Activation Viral Entry Into Host Cell Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Entry Into Host Cell Rhythmic Process Regulation Of Vasoconstriction Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Migration Chemical Homeostasis Positive Regulation Of Cell Motility Response To Organic Cyclic Compound Positive Regulation Of Cellular Component Movement Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Locomotion Negative Regulation Of Apoptotic Process Transmembrane Transport Negative Regulation Of Programmed Cell Death Ion Transport Alkanesulfonate Metabolic Process Response To Sulfur Dioxide D-alanine Transport
Tagcloud ?		adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators nfe2l2 pn proneural psychoactive redox regrowth renewal reprogramming resist ros solute sox2 taqman therapeutics xc xct	adenocarcinoma anchorage approved braf cd74 consisting constitutively driver druggable erbb4 exclusively ezr fusion fusions her3 ima imas kiaa1468 kras mucinous mutually nih3t3 nrg1 oncogenic ret sequencing transcriptome trim24 tumorigenicity
Tagcloud (Difference) ?		adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators nfe2l2 pn proneural psychoactive redox regrowth renewal reprogramming resist ros solute sox2 taqman therapeutics xc xct	adenocarcinoma anchorage approved braf cd74 consisting constitutively driver druggable erbb4 exclusively ezr fusion fusions her3 ima imas kiaa1468 kras mucinous mutually nih3t3 nrg1 oncogenic ret sequencing transcriptome trim24 tumorigenicity
Tagcloud (Intersection) ?