MKRN2 and PALS2

		MKRN2	PALS2
Description		makorin ring finger protein 2	protein associated with LIN7 2, MAGUK p55 family member
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Plasma Membrane Cell-cell Junction Membrane Organelle Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Negative Regulation Of Inflammatory Response To Antigenic Stimulus DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Protein Ubiquitination Cell Differentiation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Non-canonical NF-kappaB Signal Transduction	Protein-containing Complex Assembly
Pathways
Drugs
Diseases
GWAS		Hip index ( 34021172) Monocyte percentage of white cells ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: AIRIM CLK1 EIF3F IGF2BP3 NDN PDLIM2 RACK1 RBCK1 RELA UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3	31 interacting genes: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 MTREX NDN NFKB1 OGT PARN RPS20 SMARCA4 SNX9 THOP1 VPS26C WEE2-AS1
Entrez ID		23609	51678
HPRD ID		09761	09509
Ensembl ID		ENSG00000075975	ENSG00000105926
Uniprot IDs		Q9H000	B8ZZG1 Q9NZW5
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Protein Metabolic Process Macromolecule Catabolic Process Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Translation Regulator Activity Ubiquitin Protein Ligase Binding Regulation Of Protein Modification Process Translation Positive Regulation Of Protein Modification Process Protein Modification Process Transferase Activity Positive Regulation Of Protein Metabolic Process Protein K11-linked Ubiquitination ATP Binding Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process NF-kappaB P50/p65 Complex Positive Regulation Of Non-canonical NF-kappaB Signal Transduction IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Protein Catabolic Process Nucleus Cytosol Positive Regulation Of NF-kappaB Transcription Factor Activity	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing MRNA Catabolic Process RNA Catabolic Process Exoribonuclease Complex SnRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process RRNA 3'-end Processing TRNA Decay RRNA Processing RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleolus RNA Metabolic Process CUT Catabolic Process RNA Processing Negative Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Macromolecule Catabolic Process DNA Deamination Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA Cytoplasm Catabolic Process DNA Modification Negative Regulation Of Macromolecule Metabolic Process
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