CORO1C and MMP14

Number of citations of the paper that reports this interaction (PubMedID 31677819)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CORO1C	MMP14
Description		coronin 1C	matrix metallopeptidase 14
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Actin Cytoskeleton Membrane Lateral Plasma Membrane Flotillin Complex Sarcomere Lamellipodium Vesicle Ruffle Membrane Sarcolemma Cell Projection Synapse	Extracellular Space Nucleus Cytoplasm Golgi Lumen Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Cytoplasmic Vesicle Melanosome Macropinosome Intermediate Filament Cytoskeleton
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Actin Filament Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Neural Crest Cell Migration Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Phagocytosis Actin Filament Organization Signal Transduction Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial Cell Migration Regulation Of Fibroblast Migration Endosomal Transport Ventricular System Development Corpus Callosum Development Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Establishment Of Protein Localization Positive Regulation Of Osteoclast Differentiation Macrophage Chemotaxis Negative Regulation Of Cellular Component Organization Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Membrane Fission Activation Of GTPase Activity Endosome Membrane Tubulation Endosome Fission Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Ruffle Assembly Positive Regulation Of Lamellipodium Morphogenesis	Skeletal System Development Ossification Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Myotube Differentiation Positive Regulation Of Protein Processing Cell Migration Protein Processing Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Positive Regulation Of B Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Cell Motility Negative Regulation Of Focal Adhesion Assembly Head Development Bone Development Cellular Response To Genistein Craniofacial Suture Morphogenesis GDF15-GFRAL Signaling Pathway Negative Regulation Of GDF15-GFRAL Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macrophage Migration Response To Odorant
Pathways			Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases TGFBR3 PTM regulation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Marimastat
Diseases
GWAS		Acne (severe) ( 24927181) Brain morphology (MOSTest) ( 32665545) Coronary artery disease and LDL cholesterol levels (multivariate analysis) ( 30525989) Heel bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin ( 32888494) Immature fraction of reticulocytes ( 32888494) Low high density lipoprotein cholesterol levels ( 26879886) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)	Appendicular lean mass ( 33097823) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 30224653) Dupuytren's disease ( 28886342) Heel bone mineral density ( 28869591 30598549) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		8 interacting genes: ANXA1 CEBPA ERCC6 LMO2 MMP14 RAC1 RSPH1 TIMP4	44 interacting genes: ACAN ACE2 ADI1 AQP6 BCAR1 C1QBP CAV1 CCL7 CCN2 CCN5 CLDN1 CORO1C CXCL8 EBP ELOVL4 F11R F12 FHL3 FURIN HSD17B13 ITGAV KASH5 KISS1 LRP1 LUM MMP13 MMP2 MMP3 MSMO1 PLLP RRAD SDC1 SLPI SPOCK1 SPOCK3 STOM TGM2 TIMP2 TIMP3 TIMP4 TMEM31 TNF TNFRSF21 ZUP1
Entrez ID		23603	4323
HPRD ID		09244	02856
Ensembl ID		ENSG00000110880	ENSG00000157227
Uniprot IDs		Q9ULV4	P50281
PDB IDs		7STY	1BQQ 1BUV 2MQS 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U 6CLZ 6CM1
Enriched GO Terms of Interacting Partners?		Response To Phenylpropanoid Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Immune System Process Regulation Of Cell Development Cellular Developmental Process Positive Regulation Of Cell Activation Regulation Of Leukocyte Migration Extracellular Matrix Phagocytic Cup Response To Hormone Focal Adhesion Cell Surface Receptor Signaling Pathway Actin Filament Regulation Of Hemopoiesis Positive Regulation Of Protein Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Regulation Of Protein Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Cell-substrate Junction Organization Cellular Response To Genistein Regulation Of Focal Adhesion Assembly Negative Regulation Of GDF15-GFRAL Signaling Pathway Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Melanosome Lung Development Positive Regulation Of Metabolic Process Negative Regulation Of Hemopoiesis Positive Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Multicellular Organismal-level Homeostasis Notch Signaling Pathway CHOP-C/EBP Complex Response To Odorant Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Radial Spoke Head 1 Radial Spoke Head 3 Regulation Of Cell-matrix Adhesion Inflammatory Response Response To Glucocorticoid	Extracellular Matrix Extracellular Space Extracellular Region Metalloendopeptidase Inhibitor Activity Regulation Of Membrane Protein Ectodomain Proteolysis Enzyme Inhibitor Activity Regulation Of Entry Of Bacterium Into Host Cell Symbiont Entry Into Host Cell Response To Amyloid-beta Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Cell Motility Regulation Of Locomotion Biological Process Involved In Interaction With Host Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Endopeptidase Activity Regulation Of Cell Migration Regulation Of Cell Adhesion Regulation Of Proteolysis Regulation Of Transcytosis Extracellular Matrix Disassembly Peptidase Inhibitor Activity Positive Regulation Of Cell Migration Cell Migration Positive Regulation Of Cell Motility Endocytosis Membrane Raft Positive Regulation Of Locomotion Collagen Binding Collagen Metabolic Process Regulation Of Viral Process Leukocyte Migration Regulation Of Bicellular Tight Junction Assembly Apoptotic Cell Clearance Negative Regulation Of Proteolysis Viral Translation Viral Life Cycle Regulation Of Protein Catabolic Process Serine-type Endopeptidase Activity Regulation Of Multicellular Organismal Process Humoral Immune Response Heparin Binding Cell Motility Regulation Of Cell Junction Assembly Virus Receptor Activity Extracellular Matrix Binding Response To Cytokine Response To Peptide Receptor-mediated Endocytosis
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