CORO1C and TIMP4

Number of citations of the paper that reports this interaction (PubMedID 31677819)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CORO1C	TIMP4
Description		coronin 1C	TIMP metallopeptidase inhibitor 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Actin Cytoskeleton Membrane Lateral Plasma Membrane Flotillin Complex Sarcomere Lamellipodium Vesicle Ruffle Membrane Sarcolemma Cell Projection Synapse	Extracellular Region Extracellular Space Extracellular Matrix Secretory Granule Lumen
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Actin Filament Binding	Enzyme Inhibitor Activity Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Neural Crest Cell Migration Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Phagocytosis Actin Filament Organization Signal Transduction Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial Cell Migration Regulation Of Fibroblast Migration Endosomal Transport Ventricular System Development Corpus Callosum Development Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Establishment Of Protein Localization Positive Regulation Of Osteoclast Differentiation Macrophage Chemotaxis Negative Regulation Of Cellular Component Organization Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Membrane Fission Activation Of GTPase Activity Endosome Membrane Tubulation Endosome Fission Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Ruffle Assembly Positive Regulation Of Lamellipodium Morphogenesis	Notch Signaling Pathway Response To Hormone Response To Cytokine Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Pathways
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Brain morphology (MOSTest) ( 32665545) Coronary artery disease and LDL cholesterol levels (multivariate analysis) ( 30525989) Heel bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin ( 32888494) Immature fraction of reticulocytes ( 32888494) Low high density lipoprotein cholesterol levels ( 26879886) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)	Blood protein levels ( 30072576) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: ANXA1 CEBPA ERCC6 LMO2 MMP14 RAC1 RSPH1 TIMP4	4 interacting genes: CORO1C ERRFI1 MMP14 MMP2
Entrez ID		23603	7079
HPRD ID		09244	03557
Ensembl ID		ENSG00000110880	ENSG00000157150
Uniprot IDs		Q9ULV4	Q99727
PDB IDs		7STY
Enriched GO Terms of Interacting Partners?		Response To Phenylpropanoid Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Immune System Process Regulation Of Cell Development Cellular Developmental Process Positive Regulation Of Cell Activation Regulation Of Leukocyte Migration Extracellular Matrix Phagocytic Cup Response To Hormone Focal Adhesion Cell Surface Receptor Signaling Pathway Actin Filament Regulation Of Hemopoiesis Positive Regulation Of Protein Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Regulation Of Protein Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Cell-substrate Junction Organization Cellular Response To Genistein Regulation Of Focal Adhesion Assembly Negative Regulation Of GDF15-GFRAL Signaling Pathway Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Melanosome Lung Development Positive Regulation Of Metabolic Process Negative Regulation Of Hemopoiesis Positive Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Multicellular Organismal-level Homeostasis Notch Signaling Pathway CHOP-C/EBP Complex Response To Odorant Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Radial Spoke Head 1 Radial Spoke Head 3 Regulation Of Cell-matrix Adhesion Inflammatory Response Response To Glucocorticoid	Cell Migration Macrophage Chemotaxis Chondrocyte Proliferation Negative Regulation Of Focal Adhesion Assembly Macrophage Migration Cell Motility Endodermal Cell Differentiation Negative Regulation Of Cell Adhesion Collagen Catabolic Process Negative Regulation Of Cell-matrix Adhesion Embryo Implantation Ovarian Follicle Development Extracellular Matrix Disassembly Sarcomere Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Estrogen Negative Regulation Of Cell-substrate Adhesion Collagen Metabolic Process Regulation Of Focal Adhesion Assembly Negative Regulation Of Protein Kinase Activity Animal Organ Morphogenesis Regulation Of Cell-substrate Junction Organization Negative Regulation Of Kinase Activity Tissue Remodeling Endopeptidase Activity Metalloendopeptidase Activity Response To Hormone Enzyme-linked Receptor Protein Signaling Pathway Mononuclear Cell Migration Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Negative Regulation Of Protein Phosphorylation Response To Estradiol Skeletal System Morphogenesis Negative Regulation Of Phosphorylation Regulation Of Cell-matrix Adhesion Ossification Myeloid Leukocyte Migration Metallopeptidase Activity Ameboidal-type Cell Migration Leukocyte Chemotaxis Regulation Of Cell Adhesion Serine-type Endopeptidase Activity Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Developmental Process Involved In Reproduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Epithelial Cell Proliferation
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