HEBP2 and PDCD6

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		HEBP2	PDCD6
Gene Name		heme binding protein 2	programmed cell death 6
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Extracellular Vesicular Exosome	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Protein Homodimerization Activity Protein Anchor Protein Dimerization Activity Calcium-dependent Protein Binding Binding, Bridging
	Biological Process	Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Necrotic Cell Death Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Response To Reactive Oxygen Species	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Proteolysis Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis Response To Calcium Ion Negative Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: LRPPRC PDCD6	18 interactors: ANXA11 ANXA7 CDKN2A CPNE1 CPNE2 CPNE4 FAS FASLG HEBP2 IGFALS MAP3K5 MAPK1IP1L PDCD6IP PEF1 SH3KBP1 TIMM22 VPS37C YWHAQ
Entrez ID		23593	10016
HPRD ID		09316	03035
Ensembl ID			ENSG00000249915
Uniprot IDs		Q9Y5Z4	O75340 Q53FC3
PDB IDs		3R85 3R8J 3R8K 4AYZ 4B0Y	2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Mitochondrial RNA Catabolic Process Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Regulation Of Mitochondrial Translation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Mitochondrion Transport Along Microtubule Establishment Of Mitochondrion Localization Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Mitochondrion Localization Negative Regulation Of Protein Kinase B Signaling Intracellular Transport Organelle Transport Along Microtubule Positive Regulation Of Endothelial Cell Migration Regulation Of TOR Signaling Positive Regulation Of Endothelial Cell Proliferation Cellular Response To Heat Positive Regulation Of Epithelial Cell Migration Regulation Of Cellular Protein Metabolic Process Regulation Of Endothelial Cell Proliferation Establishment Of Localization In Cell Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Zymogen Activation Regulation Of Endothelial Cell Migration Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Heat Response To Calcium Ion Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process MRNA Transport Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Kinase B Signaling Cellular Localization Positive Regulation Of Angiogenesis Positive Regulation Of Endopeptidase Activity Microtubule-based Transport RNA Transport Cytoskeleton-dependent Intracellular Transport Regulation Of Epithelial Cell Migration Positive Regulation Of Peptidase Activity RNA Localization Positive Regulation Of Epithelial Cell Proliferation	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Processing Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Cell Death Death Positive Regulation Of Peptidase Activity Programmed Necrotic Cell Death Necrotic Cell Death Necroptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Response To Inorganic Substance Membrane Organization Inflammatory Cell Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Response To Metal Ion Response To Calcium Ion Apoptotic Signaling Pathway T Cell Apoptotic Process Cell Separation After Cytokinesis Regulation Of Endopeptidase Activity Virion Assembly Regulation Of Peptidase Activity Necroptotic Process Regulation Of Cell Death Negative Regulation Of B Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Proteolysis Mitochondrial Membrane Organization Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death Regulation Of ERBB Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Motor Neuron Apoptotic Process Regulation Of Apoptotic Process Mitochondrion Organization Cytokinesis, Completion Of Separation Senescence-associated Heterochromatin Focus Assembly Endosomal Lumen Acidification
Tagcloud ?			adp bax bcl caspase cdk4 cisplatin cleavages define irradiation luciferase ovarian overexpressing p16 p21 p27 parp pdk1 poly pro programmed regulators ribose skov suppressing tnfalpha tumorigenesis uv xl
Tagcloud (Difference) ?			adp bax bcl caspase cdk4 cisplatin cleavages define irradiation luciferase ovarian overexpressing p16 p21 p27 parp pdk1 poly pro programmed regulators ribose skov suppressing tnfalpha tumorigenesis uv xl
Tagcloud (Intersection) ?