EDA and TMEM50B

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		EDA	TMEM50B
Name		ectodysplasin A	transmembrane protein 50B
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Membrane Apical Part Of Cell	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity	Protein Binding
	Biological Process	Hair Follicle Development Immune Response Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cell Differentiation Odontogenesis Of Dentin-containing Tooth Odontogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Skin Development Canonical Wnt Signaling Pathway Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
Pathways		TNFs bind their physiological receptors	None
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia	None
GWAS		Male-pattern baldness ( 30573740 ) Metabolite levels ( 23823483 ) Monobrow ( 27182965 ) Primary tooth development (number of teeth) ( 20195514 23704328 ) Primary tooth development (time to first tooth eruption) ( 20195514 23704328 ) Tooth agenesis (maxillary lateral incisors) ( 29364747 )	Crohn's disease ( 23128233 ) Educational attainment ( 25201988 )
Interacting Genes		23 interacting genes: ATP6V0C CTXN3 CYB561 DOLK EDA2R EDAR EMP1 EMP3 FURIN GIMAP5 LEPROTL1 LPAR3 MAL MS4A13 OSTC OSTCP1 PLN PMP22 SEC22A SLC38A7 TMEM42 TMEM50B TMEM60	21 interacting genes: AMIGO1 BCL2L1 CLRN1 CREB3L1 EDA FAM209A FXYD3 GPR152 GPX8 HLA-DPA1 LEPROTL1 LHFPL5 NCR1 SCN3B SLC10A6 SLC16A13 SLC35H1 TMEM14B TMEM52B TMEM88 TMX2
Entrez ID		1896	757
HPRD ID		02347	10747
Ensembl ID		ENSG00000158813	ENSG00000142188
Uniprot IDs		A0A0U5J797 Q92838	F8WDH1 P56557 Q2V8N0
PDB IDs		1RJ7 1RJ8 7X9G	Not available
GO Terms Enriched among Interactors		Bleb Assembly Membrane Lysosomal Membrane Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Epidermis Development Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Dolichol Kinase Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity	Membrane Mitochondrial Membrane