CABIN1 and GRM1

Number of citations of the paper that reports this interaction (PubMedID 19717561)
35

Data Source:
BioGRID (pull down)

		CABIN1	GRM1
Description		calcineurin binding protein 1	glutamate metabotropic receptor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome	Nucleus Plasma Membrane Postsynaptic Density Membrane Dendrite G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Homodimeric Complex Cell Projection Neuron Projection Dendriole Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding Nucleosome Binding	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Chromatin Organization Nucleosome Assembly Cell Surface Receptor Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Regulation Of Membrane Potential Positive Regulation Of MAPK Cascade Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Electrical Stimulus L-glutamate Import Across Plasma Membrane Synaptic Signaling Via Neuropeptide Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)	G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs			Glutamic acid (S)-alpha-methyl-4-carboxyphenylglycine
Diseases
GWAS		Acne (severe) ( 24927181) Amyotrophic lateral sclerosis ( 23624525) Coronary artery disease ( 29212778) Femur bone mineral density x serum urate levels interaction ( 34046847) Monocyte count ( 32888494) S-phenylmercapturic acid levels in smokers ( 26959369) Urinary metabolite levels in chronic kidney disease ( 31959995)	Cerebral amyloid deposition (PET imaging) ( 26252872) Suicide ( 31476763) Waist circumference ( 29212154)
Interacting Genes		13 interacting genes: AMPH BORCS8-MEF2B CALM1 CAMK4 DNM1 GRM1 LCOR MEF2B MEF2D PPP3CA PPP3CB PPP3CC YWHAQ	41 interacting genes: ADORA1 BECN1 CABIN1 CASR CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C EFNB2 EPB41L2 EPHA2 ERBB2 FGFR4 GAPDH GPRASP1 GRK2 HOMER1 HOMER2 IGF1R ITPR1 KAT2A KDELR2 LATS2 MAP2K5 MYC NF2 OPRM1 OPTN PDGFRA PRKCA RAF1 RASSF1 STK11 TAMALIN TERT TTYH2 TUBB USP7
Entrez ID		23523	2911
HPRD ID		10369	05129
Ensembl ID		ENSG00000099991	ENSG00000152822
Uniprot IDs		A0A087WWW8 Q9Y6J0	Q13255 Q59HC2
PDB IDs		1N6J	3KS9 4OR2 7DGD 7DGE
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Monoatomic Ion Transmembrane Transport Calcineurin-mediated Signaling Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Protein Serine/threonine Phosphatase Complex Histone Deacetylase Binding Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Protein Dimerization Activity Negative Regulation Of Cation Transmembrane Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Import Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Import Calcium-mediated Signaling Positive Regulation Of Calcium-mediated Signaling Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Calmodulin Binding Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Regulation Of Monoatomic Cation Transmembrane Transport Heart Development Positive Regulation Of Calcium Ion Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Muscle Organ Development Regulation Of Metal Ion Transport Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Dephosphorylation Cardiac Muscle Hypertrophy Regulation Of Synaptic Vesicle Endocytosis Phosphoprotein Phosphatase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Muscle Structure Development	Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Regulation Of Cell Cycle Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Surface Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Protein Phosphorylation Regulation Of Protein Localization Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial Cell Proliferation Phosphorylation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signal Transduction Intracellular Signaling Cassette Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Response To Growth Factor Regulation Of Cell Cycle Process Transferase Activity Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction ATP Binding Cell Cycle Phase Transition Regulation Of Apoptotic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Apoptotic Process Protein Serine/threonine Kinase Activity Regulation Of Programmed Cell Death Regulation Of Cell Cycle G1/S Phase Transition Nucleotide Binding Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation
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