CABIN1 and CAMK4

Number of citations of the paper that reports this interaction (PubMedID 15902271)
43

Data Source:
BioGRID (enzymatic study)

		CABIN1	CAMK4
Description		calcineurin binding protein 1	calcium/calmodulin dependent protein kinase IV
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Extracellular Exosome
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding Nucleosome Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Cell Surface Receptor Signaling Pathway	Adaptive Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Signal Transduction Long-term Memory Regulation Of T Cell Differentiation In Thymus Intracellular Signal Transduction Myeloid Dendritic Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Transcriptional activation of mitochondrial biogenesis CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs			K-00546 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
Diseases
GWAS		Acne (severe) ( 24927181) Amyotrophic lateral sclerosis ( 23624525) Coronary artery disease ( 29212778) Femur bone mineral density x serum urate levels interaction ( 34046847) Monocyte count ( 32888494) S-phenylmercapturic acid levels in smokers ( 26959369) Urinary metabolite levels in chronic kidney disease ( 31959995)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 30929738 31959851 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Blood pressure ( 17903302) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Motor coordination ( 34177493) Periodontitis (PAL4Q3) ( 24024966) Self-reported allergy ( 23817569) Type 1 diabetes ( 34012112)
Interacting Genes		13 interacting genes: AMPH BORCS8-MEF2B CALM1 CAMK4 DNM1 GRM1 LCOR MEF2B MEF2D PPP3CA PPP3CB PPP3CC YWHAQ	10 interacting genes: CABIN1 CAMKK1 CAMKK2 CREBBP GAPDH HDAC4 NEDD4 NOS1 NOTCH1 RELA
Entrez ID		23523	814
HPRD ID		10369	07169
Ensembl ID		ENSG00000099991	ENSG00000152495
Uniprot IDs		A0A087WWW8 Q9Y6J0	Q16566
PDB IDs		1N6J	2W4O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Monoatomic Ion Transmembrane Transport Calcineurin-mediated Signaling Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Protein Serine/threonine Phosphatase Complex Histone Deacetylase Binding Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Protein Dimerization Activity Negative Regulation Of Cation Transmembrane Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Import Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Import Calcium-mediated Signaling Positive Regulation Of Calcium-mediated Signaling Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Calmodulin Binding Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Regulation Of Monoatomic Cation Transmembrane Transport Heart Development Positive Regulation Of Calcium Ion Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Muscle Organ Development Regulation Of Metal Ion Transport Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Dephosphorylation Cardiac Muscle Hypertrophy Regulation Of Synaptic Vesicle Endocytosis Phosphoprotein Phosphatase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Muscle Structure Development	Peptidyl-cysteine S-nitrosylase Activity Chromatin DNA Binding Nucleus Nucleoplasm Cytosol Endocardial Cushion Development Negative Regulation Of Myotube Differentiation Response To Muramyl Dipeptide Calcium/calmodulin-dependent Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Response To UV Response To Stress Regulation Of Protein Sumoylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Regulation Of Gene Expression NADP Binding Calmodulin Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Regulation Of Myotube Differentiation Rhythmic Process Transcription Coactivator Binding Negative Regulation Of Metabolic Process Immune System Process Positive Regulation Of Transcription By RNA Polymerase II Canonical NF-kappaB Signal Transduction Catabolic Process Mesenchyme Development Formation Of Structure Involved In A Symbiotic Process Cellular Response To Growth Factor Stimulus Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?