MORC3 and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		MORC3	KPNA4
Description		MORC family CW-type zinc finger 3	karyopherin subunit alpha 4
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Matrix PML Body	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding Zinc Ion Binding ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Metal Ion Binding Histone H3K4me3 Reader Activity	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Chromatin Organization Protein Phosphorylation Post-embryonic Development Peptidyl-serine Phosphorylation Negative Regulation Of Interferon-beta Production Innate Immune Response Negative Regulation Of Fibroblast Proliferation Protein Stabilization Maintenance Of Protein Location In Nucleus Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response Positive Regulation Of Cellular Senescence	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide
Pathways			ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Height ( 31562340)	Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		25 interacting genes: ARK2N COPS5 DST DYNLL1 ERCC6 KALRN KIF3A KPNA2 KPNA4 MKLN1 PIAS1 PIAS3 PTK2 RANBP9 RETREG1 RNF123 RNF216 SNAPIN SPTBN4 SRI SUMO2 SUMO3 UBC UBE2I ZMYM5	49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3
Entrez ID		23515	3840
HPRD ID		10316	04275
Ensembl ID		ENSG00000159256	ENSG00000186432
Uniprot IDs		B4DHJ4 Q14149 Q4VBZ9	O00629
PDB IDs		4QQ4 5SVI 5SVX 5SVY 6O1E 6O5W	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW
Enriched GO Terms of Interacting Partners?		Protein Sumoylation SUMO Transferase Activity Protein Modification By Small Protein Conjugation Presynaptic Cytosol Postsynaptic Cytosol Post-translational Protein Modification PML Body Protein Modification Process Protein Tag Activity Axon Cytoplasm Protein Metabolic Process Cytoskeleton-dependent Intracellular Transport Establishment Of Localization In Cell Nucleoplasm Macromolecule Metabolic Process NLS-dependent Protein Nuclear Import Complex Intracellular Transport Microtubule Anchoring At Centrosome Cellular Localization Axonal Transport Negative Regulation Of Heart Rate SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Microtubule Anchoring At Microtubule Organizing Center Transport Along Microtubule Cell Cortex Axo-dendritic Transport Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Cytosol Microtubule-based Transport Nuclear Import Signal Receptor Activity Retrograde Axonal Transport Negative Regulation Of Heart Contraction Cytoplasm Enzyme Binding Nuclear Localization Sequence Binding Negative Regulation Of Blood Circulation Regulation Of Protein Sumoylation NLS-bearing Protein Import Into Nucleus Microtubule Anchoring Regulation Of Protein Modification Process Establishment Of Vesicle Localization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Spectrin Binding Proteolysis Involved In Protein Catabolic Process Establishment Of Organelle Localization Vesicle Localization	Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process
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