MORC3 and MKLN1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		MORC3	MKLN1
Description		MORC family CW-type zinc finger 3	muskelin 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Matrix PML Body	Ubiquitin Ligase Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Cell Cortex Cell Projection Synapse Postsynapse Postsynaptic Endosome Membrane GABA-ergic Synapse Postsynaptic Specialization Membrane Of Symmetric Synapse
	Molecular Function	DNA Binding RNA Binding Protein Binding Zinc Ion Binding ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Metal Ion Binding Histone H3K4me3 Reader Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Chromatin Organization Protein Phosphorylation Post-embryonic Development Peptidyl-serine Phosphorylation Negative Regulation Of Interferon-beta Production Innate Immune Response Negative Regulation Of Fibroblast Proliferation Protein Stabilization Maintenance Of Protein Location In Nucleus Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response Positive Regulation Of Cellular Senescence	Regulation Of Receptor Internalization Cell-matrix Adhesion Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Vesicle-mediated Transport In Synapse
Pathways			Regulation of pyruvate metabolism
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Height ( 31562340)	Asthma (childhood onset) ( 23829686) Bipolar disorder ( 31043756) Bipolar disorder (early onset) ( 27769005) Cutaneous malignant melanoma ( 32341527) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Hyperglycemia in higher physical activity ( 30327367) Hypertension ( 28273873) Lung cancer in never smokers ( 28604730) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Myeloproliferative neoplasms ( 33057200) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Pancreatic cancer ( 25086665) PR interval ( 30046033 32439900) Refractive error ( 32231278) Resting heart rate ( 27798624) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Systolic blood pressure ( 28135244) Vitamin D levels ( 25208829) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		25 interacting genes: ARK2N COPS5 DST DYNLL1 ERCC6 KALRN KIF3A KPNA2 KPNA4 MKLN1 PIAS1 PIAS3 PTK2 RANBP9 RETREG1 RNF123 RNF216 SNAPIN SPTBN4 SRI SUMO2 SUMO3 UBC UBE2I ZMYM5	5 interacting genes: CYREN LAMTOR5 MORC3 PTGER3 ZBTB2
Entrez ID		23515	4289
HPRD ID		10316	16129
Ensembl ID		ENSG00000159256	ENSG00000128585
Uniprot IDs		B4DHJ4 Q14149 Q4VBZ9	B4DG30 C9J7E8 Q9UL63
PDB IDs		4QQ4 5SVI 5SVX 5SVY 6O1E 6O5W	8TTQ
Enriched GO Terms of Interacting Partners?		Protein Sumoylation SUMO Transferase Activity Protein Modification By Small Protein Conjugation Presynaptic Cytosol Postsynaptic Cytosol Post-translational Protein Modification PML Body Protein Modification Process Protein Tag Activity Axon Cytoplasm Protein Metabolic Process Cytoskeleton-dependent Intracellular Transport Establishment Of Localization In Cell Nucleoplasm Macromolecule Metabolic Process NLS-dependent Protein Nuclear Import Complex Intracellular Transport Microtubule Anchoring At Centrosome Cellular Localization Axonal Transport Negative Regulation Of Heart Rate SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Microtubule Anchoring At Microtubule Organizing Center Transport Along Microtubule Cell Cortex Axo-dendritic Transport Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Cytosol Microtubule-based Transport Nuclear Import Signal Receptor Activity Retrograde Axonal Transport Negative Regulation Of Heart Contraction Cytoplasm Enzyme Binding Nuclear Localization Sequence Binding Negative Regulation Of Blood Circulation Regulation Of Protein Sumoylation NLS-bearing Protein Import Into Nucleus Microtubule Anchoring Regulation Of Protein Modification Process Establishment Of Vesicle Localization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Spectrin Binding Proteolysis Involved In Protein Catabolic Process Establishment Of Organelle Localization Vesicle Localization	Regulation Of Gastric Acid Secretion Positive Regulation Of Fever Generation Negative Regulation Of Gastric Acid Secretion Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Intestine Smooth Muscle Contraction Regulation Of Fever Generation Regulation Of Cytokine Production FNIP-folliculin RagC/D GAP Ragulator Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Immunoglobulin V(D)J Recombination
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