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QPRT and KRTAP10-8
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
QPRT
KRTAP10-8
Gene Name
quinolinate phosphoribosyltransferase
keratin associated protein 10-8
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Extracellular Vesicular Exosome
Keratin Filament
Molecular Function
Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity
Protein Homodimerization Activity
Biological Process
Vitamin Metabolic Process
Water-soluble Vitamin Metabolic Process
NAD Biosynthetic Process
NAD Metabolic Process
Quinolinate Catabolic Process
Small Molecule Metabolic Process
Protein Oligomerization
Pathways
Metabolism of vitamins and cofactors
Defective GIF causes intrinsic factor deficiency
Defective CD320 causes methylmalonic aciduria
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
Defective HLCS causes multiple carboxylase deficiency
Defective MMAB causes methylmalonic aciduria type cblB
Defective BTD causes biotidinase deficiency
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Defective MMAA causes methylmalonic aciduria type cblA
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defective CUBN causes hereditary megaloblastic anemia 1
Defective AMN causes hereditary megaloblastic anemia 1
Defective MUT causes methylmalonic aciduria mut type
Metabolism of water-soluble vitamins and cofactors
Defects in biotin (Btn) metabolism
Defective TCN2 causes hereditary megaloblastic anemia
Nicotinate metabolism
Defects in vitamin and cofactor metabolism
Defects in cobalamin (B12) metabolism
Drugs
Niacin
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
GIT2
KRT40
KRTAP10-3
KRTAP10-8
KRTAP4-12
NOTCH2NL
SUFU
163 interactors:
ACY3
ADAMTSL3
ADAMTSL4
AEN
AES
ALDH3B1
ALPI
APOL6
ASPSCR1
ATG9A
BEX2
BMP7
C11orf87
C19orf66
C9orf9
CARHSP1
CARKD
CATSPER1
CCDC26
CCNJL
CHIC2
CHRD
CHRNG
CLK4
CNNM3
COL8A1
CRCT1
CREB5
DAAM2
DCX
DDX55
DDX6
DERL2
DHRS1
DHX57
DMRT3
DOCK2
EIF4E2
FAH
FAM27E3
FAM74A4
FAM76B
FBXW5
FOXB1
GFOD1
GLIDR
GLP1R
GLRX3
GLYAT
GNAI2
GNE
GOLGA8EP
HHEX
HOXA1
HPCAL1
HSD3B7
HSPD1
IGSF8
ITGB5
JOSD1
KLHL38
KRT20
KRT83
KRTAP10-3
KRTAP10-7
KRTAP10-9
KRTAP12-1
KRTAP12-2
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LCE1B
LCE2A
LCE2D
LCE3C
LCE3E
LCE4A
LINC00656
LOC153684
LRCH4
LUZP4
LYVE1
MAPKBP1
MATN3
MEOX2
MLLT6
MTA1
MXI1
NAB2
NOTCH2NL
NUFIP2
OTX1
P2RX7
PCED1A
PCSK5
PDE9A
PGLS
PIGS
PKD2
POM121L8P
PRKAB2
PRPF31
PRR13
PTGER3
PTPMT1
PTPRH
PVR
PVRL3
QPRT
R3HDM2
RANBP3
RPS28
RTN4RL1
SCNM1
SLC22A23
SLC23A1
SLC25A10
SLC6A20
SMCP
SMOC1
SPATA3
SPRY1
SPRY2
STK16
SUSD6
TBC1D16
TBC1D23
THAP10
THAP7
TMEM150A
TNIP3
TNP2
TNS2
TRPV6
TXNDC5
TYMSOS
TYRO3
UTP23
UXT
VPS11
WIF1
WT1
WT1-AS
YIPF3
ZBTB24
ZFYVE21
ZNF124
ZNF138
ZNF20
ZNF32
ZNF417
ZNF439
ZNF473
ZNF572
ZNF578
ZNF587
ZNF697
ZSCAN21
Entrez ID
23475
386681
HPRD ID
06950
11194
Ensembl ID
ENSG00000187766
Uniprot IDs
Q15274
P60410
PDB IDs
2JBM
3LAR
4KWV
4KWW
Enriched GO Terms of Interacting Partners
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Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Ventral Spinal Cord Interneuron Specification
Spinal Cord Motor Neuron Cell Fate Specification
Ventral Spinal Cord Interneuron Fate Commitment
Ventral Spinal Cord Interneuron Differentiation
Cytoplasmic Sequestering Of Transcription Factor
Behavioral Response To Pain
Cytoplasmic Sequestering Of Protein
Negative Regulation Of Embryonic Development
Spinal Cord Dorsal/ventral Patterning
Neuron Fate Specification
Negative Regulation Of Smoothened Signaling Pathway
Spinal Cord Patterning
Response To Pain
Spinal Cord Motor Neuron Differentiation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Transcription Factor Import Into Nucleus
Ventral Spinal Cord Development
Heart Looping
Determination Of Heart Left/right Asymmetry
Cell Differentiation In Spinal Cord
Embryonic Heart Tube Morphogenesis
Negative Regulation Of Protein Import Into Nucleus
Regulation Of ARF GTPase Activity
Negative Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Ossification
Neuron Fate Commitment
Negative Regulation Of Protein Localization To Nucleus
Embryonic Heart Tube Development
Negative Regulation Of Intracellular Protein Transport
Multicellular Organismal Response To Stress
Regulation Of Transcription Factor Import Into Nucleus
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cell Fate Specification
Regulation Of Smoothened Signaling Pathway
Regulation Of ARF Protein Signal Transduction
Negative Regulation Of Protein Ubiquitination
Neural Tube Closure
Spinal Cord Development
Determination Of Left/right Symmetry
Determination Of Bilateral Symmetry
Regulation Of Embryonic Development
Negative Regulation Of Intracellular Transport
Smoothened Signaling Pathway
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Protein Catabolic Process
Keratinization
RNA Biosynthetic Process
Transcription, DNA-templated
Gene Expression
RNA Metabolic Process
Pattern Specification Process
Keratinocyte Differentiation
Organ Development
Epithelium Development
Cellular Nitrogen Compound Metabolic Process
Developmental Process
Nucleobase-containing Compound Metabolic Process
Nitrogen Compound Metabolic Process
Multicellular Organismal Development
Cellular Aromatic Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Epidermis Development
Tissue Development
Negative Regulation Of Glomerulus Development
Negative Regulation Of Glomerular Mesangial Cell Proliferation
Epidermal Cell Differentiation
Macromolecule Biosynthetic Process
Metanephric Mesenchyme Development
Heterocycle Metabolic Process
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Sperm Motility
Negative Regulation Of Cell Proliferation Involved In Kidney Development
Fertilization
Biosynthetic Process
Anterior/posterior Pattern Specification
Anatomical Structure Development
Epithelial Cell Differentiation
Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Metanephric S-shaped Body Morphogenesis
Single Fertilization
System Development
Branching Morphogenesis Of An Epithelial Tube
Regulation Of Glomerular Mesangial Cell Proliferation
Penetration Of Zona Pellucida
S-shaped Body Morphogenesis
Positive Regulation Of Immune Response To Tumor Cell
Floor Plate Development
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Tube Development
Skin Development
Bud Elongation Involved In Lung Branching
Morphogenesis Of A Branching Epithelium
Negative Regulation Of Mesenchymal Cell Apoptotic Process
Epithelial Tube Branching Involved In Lung Morphogenesis
Morphogenesis Of A Branching Structure
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