OTP and CCL21

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		OTP	CCL21
Name		orthopedia homeobox	C-C motif chemokine ligand 21
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Nuclear Body	Extracellular Region Extracellular Space
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding	Cytokine Activity Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuroblast Proliferation Regulation Of DNA-templated Transcription Nervous System Development Neuroblast Proliferation Forebrain Neuron Differentiation Hypothalamus Cell Differentiation Neurohypophysis Development Cell Differentiation Neuron Differentiation Neuroendocrine Cell Differentiation Dopaminergic Neuron Differentiation	Establishment Of T Cell Polarity Immunological Synapse Formation Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of T Cell Chemotaxis Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Ruffle Organization Killing Of Cells Of Another Organism Positive Regulation Of Cell Adhesion Mediated By Integrin Mesangial Cell-matrix Adhesion Chemokine (C-C Motif) Ligand 21 Signaling Pathway CCL21-activated CCR7 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Eosinophil Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Neutrophil Chemotaxis Dendritic Cell Dendrite Assembly Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Negative Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Chemokine Positive Regulation Of Cell Motility Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		None	Chemokine receptors bind chemokines G alpha (i) signalling events
GWAS		Age at first sexual intercourse ( 34211149 )	Autoimmune traits (pleiotropy) ( 30572963 ) Blood protein levels ( 30072576 ) Celiac disease ( 30572963 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Rheumatoid arthritis ( 18794853 23143596 24390342 30423114 30572963 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 )
Novel Interactors		None recorded	5 novel interactors: CCL27 DCTN3 GALT IL11RA RNF38
Interacting Genes		8 interacting genes: BEX1 CCL21 CDK6 CPNE7 EOMES PDE6D SLC12A7 TPGS2	32 interacting genes: ACKR2 ACKR4 C3orf52 CCL13 CCL17 CCL23 CCL24 CCL26 CCL28 CCL5 CCR7 CTSD CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL17 CXCL2 CXCL9 GOT2 IGFBP7 LRRK1 OTP PF4 PF4V1 PPBP TMEM107 UBQLN4 VCAN XCL1 XCL2
Entrez ID		23440	6366
HPRD ID		05166	04113
Ensembl ID		ENSG00000171540	ENSG00000137077
Uniprot IDs		Q5XKR4	O00585
PDB IDs		Not available	2L4N 5EKI
GO Terms Enriched among Interactors		Positive Regulation Of Cell-matrix Adhesion Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex FBXO Family Protein Binding Dendritic Cell Dendrite Assembly Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Mesangial Cell-matrix Adhesion CCR7 Chemokine Receptor Binding CCL21-activated CCR7 Signaling Pathway Negative Regulation Of Dendritic Cell Dendrite Assembly CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Regulation Of Cell-matrix Adhesion Stem Cell Differentiation Neurogenesis Positive Regulation Of Cell-substrate Adhesion Regulation Of Dendritic Cell Dendrite Assembly Mesodermal To Mesenchymal Transition Involved In Gastrulation	Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Cytokine Activity Leukocyte Chemotaxis Humoral Immune Response Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Leukocyte Migration Cell Migration Granulocyte Chemotaxis CXCR Chemokine Receptor Binding Cell Motility Killing Of Cells Of Another Organism Granulocyte Migration Inflammatory Response Cell Killing Cytokine-mediated Signaling Pathway Defense Response To Symbiont Immune Response Defense Response To Other Organism Extracellular Space Mononuclear Cell Migration Immune System Process Defense Response Neutrophil Chemotaxis Extracellular Region Response To Other Organism Response To External Biotic Stimulus Neutrophil Migration CXCR3 Chemokine Receptor Binding CCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Lymphocyte Chemotaxis Chemokine Receptor Binding Lymphocyte Migration Cell-cell Signaling Signaling Cell Communication Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Motility