FRAT1 and RABEP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FRAT1	RABEP2
Description		FRAT regulator of Wnt signaling pathway 1	rabaptin, RAB GTPase binding effector protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Endosome Early Endosome Golgi Apparatus Centrosome Cytosol Cytoskeleton Ciliary Basal Body Cell Projection Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Molecular Function Inhibitor Activity	GTPase Activator Activity Protein Binding Growth Factor Activity
	Biological Process	Wnt Signaling Pathway Regulation Of Protein Export From Nucleus Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Endocytosis Signal Transduction Protein Transport Cell Projection Organization Regulation Of Cilium Assembly
Pathways		Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) White blood cell count ( 32888494)	Adventurousness ( 30643258) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 31453325) Body mass index variance ( 31453325) Brain morphology (MOSTest) ( 32665545) Cannabis use ( 30150663) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Obesity ( 23563607) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		13 interacting genes: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7	6 interacting genes: FBXO25 FRAT1 MAP3K1 RAB5A VPS52 WWP2
Entrez ID		10023	79874
HPRD ID		03935	17948
Ensembl ID		ENSG00000165879	ENSG00000177548
Uniprot IDs		Q92837	Q9H5N1
PDB IDs		1GNG 3ZRK 3ZRL 3ZRM 4AFJ 5OY4
Enriched GO Terms of Interacting Partners?		Wnt Signalosome
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