FRAT1 and RABEP2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FRAT1	RABEP2
Gene Name		frequently rearranged in advanced T-cell lymphomas 1	rabaptin, RAB GTPase binding effector protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm Early Endosome Intracellular Membrane-bounded Organelle
	Molecular Function		GTPase Activator Activity Growth Factor Activity
	Biological Process	Embryonic Axis Specification Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Endocytosis Protein Transport Positive Regulation Of GTPase Activity
Pathways		misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Obesity ( 23563607)
Protein-Protein Interactions		13 interactors: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7	5 interactors: FBXO25 FRAT1 RAB4A RAB5A UBC
Entrez ID		10023	79874
HPRD ID		03935	17948
Ensembl ID		ENSG00000165879	ENSG00000177548
Uniprot IDs		Q92837	B4DHR0 Q9H5N1
PDB IDs		1GNG 3ZRK 3ZRL 3ZRM 4AFJ
Enriched GO Terms of Interacting Partners?		Protein Localization To Microtubule Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Protein Localization To Cytoskeleton Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteolysis Negative Regulation Of Protein Binding Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Golgi To Plasma Membrane CFTR Protein Transport Positive Regulation Of Proteasomal Protein Catabolic Process Transport Regulation Of Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Apoptotic Process Canonical Wnt Signaling Pathway Negative Regulation Of Binding Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Cell Death Death Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Protein Localization Establishment Of Localization In Cell Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Binding Collateral Sprouting Cellular Response To Interleukin-3 Sensory Organ Development Phosphatidylserine Biosynthetic Process Convergent Extension Involved In Organogenesis Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Neuron Maturation Protein Transport Regulation Of Catalytic Activity Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Dendrite Morphogenesis	Rab Protein Signal Transduction Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Regulation Of Endocytosis Endosomal Transport Ras Protein Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Antigen Processing And Presentation
Tagcloud ?		apc axin1 cadherin catenin ck1 colon destruction du145 elucidate emt gsk3beta ht29 inhibiting involves localization maintaining mesenchymal modulate ndrg1 pak4 precise prevents ser33 thr41 transforming translocation transporter upregulation wnt
Tagcloud (Difference) ?		apc axin1 cadherin catenin ck1 colon destruction du145 elucidate emt gsk3beta ht29 inhibiting involves localization maintaining mesenchymal modulate ndrg1 pak4 precise prevents ser33 thr41 transforming translocation transporter upregulation wnt
Tagcloud (Intersection) ?