FRAT1 and KCNK5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FRAT1	KCNK5
Description		FRAT regulator of Wnt signaling pathway 1	potassium two pore domain channel subfamily K member 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Protein Binding Molecular Function Inhibitor Activity	Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Wnt Signaling Pathway Regulation Of Protein Export From Nucleus Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane	Phase 4 - resting membrane potential
Drugs
Diseases
GWAS		Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) White blood cell count ( 32888494)	Albuminuria ( 30547231) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Coronary artery disease ( 26343387 29212778 33020668 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Eating disorders ( 23568457) Fasting plasma glucose ( 32682390) HDL cholesterol levels ( 32203549) Hypertension in type 2 diabetes ( 33276381) Kidney stones ( 31729369) Migraine ( 27322543) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Social communication problems ( 24564958) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urolithiasis ( 30975718)
Interacting Genes		13 interacting genes: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7	29 interacting genes: ADIPOQ AGTRAP APP AQP1 ATP5PF BNIP2 CMTM5 COMT CYB5B FRAT1 GJB2 IGFBP5 LHFPL5 MAN2B2 ORMDL3 SLC66A2 SMCO4 STRIT1 TM4SF4 TMEM128 TMEM14A TMEM176A TMEM218 TMEM54 TMEM60 TNFRSF10C TSPAN33 VAMP3 YIPF6
Entrez ID		10023	8645
HPRD ID		03935	04604
Ensembl ID		ENSG00000165879	ENSG00000164626
Uniprot IDs		Q92837	A0A0B6VPR3 O95279
PDB IDs		1GNG 3ZRK 3ZRL 3ZRM 4AFJ 5OY4
Enriched GO Terms of Interacting Partners?		Wnt Signalosome	Membrane Cellular Response To CAMP Response To CAMP Response To Purine-containing Compound Response To Decreased Oxygen Levels
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