ZFPM2 and GATA3

Number of citations of the paper that reports this interaction (PMID 14985365)
21

Data Source:
HPRD (two hybrid, in vitro)

		ZFPM2	GATA3
Gene Name		zinc finger protein, FOG family member 2	GATA binding protein 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity DNA Binding Transcription Corepressor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Nucleic Acid Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Enhancer Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Interleukin-2 Receptor Binding Protein Binding Transcription Factor Binding Zinc Ion Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity E-box Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis In Utero Embryonic Development Outflow Tract Septum Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Transcription, DNA-templated Gonadal Mesoderm Development Blood Coagulation Lung Development Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Development Ventricular Septum Morphogenesis Negative Regulation Of Cell Death Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Cell Fate Determination Neuron Migration Type IV Hypersensitivity Kidney Development Mesonephros Development Lens Development In Camera-type Eye Pro-T Cell Differentiation Aortic Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Transcription From RNA Polymerase II Promoter Defense Response Humoral Immune Response Signal Transduction Axon Guidance Blood Coagulation Negative Regulation Of Cell Proliferation Male Gonad Development Response To Virus Anatomical Structure Morphogenesis Post-embryonic Development Positive Regulation Of Signal Transduction Response To Gamma Radiation Positive Regulation Of Endothelial Cell Migration Regulation Of Neuron Projection Development Phosphatidylinositol 3-kinase Signaling Erythrocyte Differentiation TOR Signaling Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Embryonic Hemopoiesis Cellular Response To Interferon-alpha Ureter Maturation Parathyroid Hormone Secretion Regulation Of Cytokine Biosynthetic Process Norepinephrine Biosynthetic Process Inner Ear Morphogenesis Response To Drug Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Neuron Apoptotic Process Ear Development Response To Estrogen Thymic T Cell Selection T-helper 2 Cell Differentiation Innate Immune Response Response To Ethanol Positive Regulation Of T Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Sympathetic Nervous System Development Thymus Development Developmental Growth Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Kinase B Signaling Parathyroid Gland Development Pharyngeal System Development Uterus Development Mesenchymal To Epithelial Transition Mast Cell Differentiation Ureteric Bud Formation Regulation Of Histone H3-K27 Methylation Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor Otic Vesicle Development Cellular Response To BMP Stimulus Positive Regulation Of Ureteric Bud Formation Nephric Duct Morphogenesis Nephric Duct Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Interleukin-4 Secretion Interferon-gamma Secretion Lymphocyte Migration Regulation Of Establishment Of Cell Polarity Negative Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Positive Regulation Of Thyroid Hormone Generation Positive Regulation Of Interleukin-5 Secretion Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cellular Response To X-ray Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation
Pathways		Factors involved in megakaryocyte development and platelet production	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Glaucoma (primary open-angle) ( 22570617) Platelet counts ( 22139419) Sudden cardiac arrest ( 21658281) Vascular endothelial growth factor levels ( 21757650)	Hodgkin's lymphoma ( 21037568)
Protein-Protein Interactions		10 interactors: CTBP1 CTBP2 EP300 GATA1 GATA3 GATA4 IL32 ITSN1 STAT3 UBQLN4	13 interactors: ETS1 ETS2 LMO1 LMO2 MED1 PSMA3 RARB REPIN1 SATB1 SP1 SPI1 TAL1 ZFPM2
Entrez ID		23414	2625
HPRD ID		04737	00572
Ensembl ID		ENSG00000169946	ENSG00000107485
Uniprot IDs		Q8WW38 Q9NPQ0	P23771
PDB IDs			4HC7 4HC9 4HCA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Response To Estrogen Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Binding Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Binding Positive Regulation Of Cellular Biosynthetic Process Cardiac Right Ventricle Morphogenesis Response To Hormone White Fat Cell Differentiation Regulation Of Signal Transduction Response To Steroid Hormone Male Gonad Development Cellular Response To Organic Substance Regulation Of Transcription Regulatory Region DNA Binding Viral Genome Replication Regulation Of Signaling Viral Process Male Sex Differentiation RNA Metabolic Process Heart Valve Morphogenesis Positive Regulation Of Signal Transduction Embryonic Hemopoiesis Heart Valve Development Cell Differentiation Gonad Development Development Of Primary Sexual Characteristics Gene Expression Cellular Macromolecule Biosynthetic Process Anatomical Structure Morphogenesis Macromolecule Biosynthetic Process Sex Differentiation Response To Organic Substance Regulation Of Protein Deacetylation	Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Erythrocyte Differentiation Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Embryonic Organ Development Cardiovascular System Development Negative Regulation Of Cellular Metabolic Process Megakaryocyte Differentiation Nitrogen Compound Metabolic Process Erythrocyte Differentiation Erythrocyte Homeostasis Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Hemopoiesis Regulation Of RNA Metabolic Process Embryonic Hemopoiesis Myeloid Cell Homeostasis Nucleobase-containing Compound Metabolic Process Cardiac Chamber Development Immune System Development Hematopoietic Progenitor Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Myeloid Cell Differentiation Blood Vessel Morphogenesis Organ Development Immune System Process
Tagcloud ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36	coactivated coexpressed cofactors collectively cryptic dehydrogenase endogeneous example exogenously forced hpb initiated intron lim lmo lymphoblastic mostly potentiated raldh2 regularly relate retinaldehyde subtractive synergistic synergy tal1 tried tumorigenesis
Tagcloud (Difference) ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36	coactivated coexpressed cofactors collectively cryptic dehydrogenase endogeneous example exogenously forced hpb initiated intron lim lmo lymphoblastic mostly potentiated raldh2 regularly relate retinaldehyde subtractive synergistic synergy tal1 tried tumorigenesis
Tagcloud (Intersection) ?