ZFPM2 and IL32

Number of citations of the paper that reports this interaction (PubMedID 25178676)
0

Data Source:
BioGRID (two hybrid)

		ZFPM2	IL32
Description		zinc finger protein, FOG family member 2	interleukin 32
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm	Extracellular Region Extracellular Space Cytosol Membrane
	Molecular Function	DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Cytokine Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis In Utero Embryonic Development Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Transcription By RNA Polymerase II Gonadal Mesoderm Development Heart Development Cell Differentiation Lung Development Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Defense Response Immune Response Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Type III Interferon Production Negative Regulation Of Viral Life Cycle
Pathways		Transcriptional regulation of testis differentiation Factors involved in megakaryocyte development and platelet production	Other interleukin signaling RAC3 GTPase cycle
Drugs
Diseases		Tetralogy of Fallot
GWAS		Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Basophil count ( 32888494) Birth weight ( 31043758) Brugada syndrome ( 35210625) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778 33020668) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma (primary open-angle) ( 22570617) HDL cholesterol levels ( 32203549) HOMA-B (corrected for HOMA-IR) ( 30369944) Impulsivity (attentional) ( 30718321) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Neutrophil count ( 32888494) Platelet count ( 32888494 29403010 33545615 27863252 26805783 22139419) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 27863252 32888494) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 28739976) Takayasu arteritis ( 25604533) Tuberculosis ( 24057671) Vascular endothelial growth factor levels ( 21757650 26910538) Venous thromboembolism ( 31676865 31420334 28373160 25772935) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) HIV-1 susceptibility ( 22174851) Liver enzyme levels (alanine transaminase) ( 33972514)
Interacting Genes		13 interacting genes: CTBP1 CTBP2 E2F6 EP300 FMR1 GATA1 GATA3 GATA4 IL32 ITSN1 PRPF3 STAT3 UBQLN4	11 interacting genes: C1QB HSPA8 KPNA5 NDN NQO2 PRTN3 RHBDD2 RPL4 SNRNP70 TUT1 ZFPM2
Entrez ID		23414	9235
HPRD ID		04737	09346
Ensembl ID		ENSG00000169946	ENSG00000008517
Uniprot IDs		E7ET52 Q8WW38 Q9NPQ0	C6GKH1 G3LU47 P24001
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Coregulator Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Cell Fate Commitment Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Autophagy Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Male Gonad Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Gonad Development Negative Regulation Of Metabolic Process Transcription Coactivator Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Reproductive Structure Development Transcription Repressor Complex Identical Protein Binding Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Developmental Process Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Chromatin DNA Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T-helper 17 Cell Lineage Commitment Transcription Cis-regulatory Region Binding Cardiac Right Ventricle Morphogenesis Nucleic Acid Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA White Fat Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process T-helper Cell Lineage Commitment Chromatin Viral Genome Replication DNA-binding Transcription Factor Activity CD4-positive, Alpha-beta T Cell Lineage Commitment Fat Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulator Complex Platelet Formation Alpha-beta T Cell Lineage Commitment Embryonic Hemopoiesis
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