ZFPM2 and GATA1

Number of citations of the paper that reports this interaction (PubMedID 10438528)
0

Data Source:
HPRD (two hybrid, in vitro)

		ZFPM2	GATA1
Description		zinc finger protein, FOG family member 2	GATA binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis In Utero Embryonic Development Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Transcription By RNA Polymerase II Gonadal Mesoderm Development Heart Development Cell Differentiation Lung Development Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Anatomical Structure Morphogenesis Regulation Of Glycoprotein Biosynthetic Process Regulation Of Definitive Erythrocyte Differentiation Regulation Of Primitive Erythrocyte Differentiation Myeloid Cell Differentiation Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Eosinophil Differentiation Bone Mineralization Negative Regulation Of Bone Mineralization Animal Organ Regeneration Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Osteoblast Proliferation Positive Regulation Of Osteoblast Proliferation Embryonic Hemopoiesis Eosinophil Fate Commitment Negative Regulation Of Apoptotic Process Positive Regulation Of Mast Cell Degranulation Cell Fate Commitment Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development System Development Erythrocyte Development Homeostasis Of Number Of Cells Within A Tissue Sertoli Cell Development Primitive Erythrocyte Differentiation Platelet Aggregation Cellular Response To Lipopolysaccharide Cellular Response To CAMP Cellular Response To Follicle-stimulating Hormone Stimulus Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Transcriptional regulation of testis differentiation Factors involved in megakaryocyte development and platelet production	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		Tetralogy of Fallot	Congenital dyserythropoietic anemias (CDAs) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Basophil count ( 32888494) Birth weight ( 31043758) Brugada syndrome ( 35210625) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778 33020668) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma (primary open-angle) ( 22570617) HDL cholesterol levels ( 32203549) HOMA-B (corrected for HOMA-IR) ( 30369944) Impulsivity (attentional) ( 30718321) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Neutrophil count ( 32888494) Platelet count ( 32888494 29403010 33545615 27863252 26805783 22139419) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 27863252 32888494) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 28739976) Takayasu arteritis ( 25604533) Tuberculosis ( 24057671) Vascular endothelial growth factor levels ( 21757650 26910538) Venous thromboembolism ( 31676865 31420334 28373160 25772935) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)	Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		13 interacting genes: CTBP1 CTBP2 E2F6 EP300 FMR1 GATA1 GATA3 GATA4 IL32 ITSN1 PRPF3 STAT3 UBQLN4	86 interacting genes: AKT1 ARID1A ARMC7 ATP6V0D1 BCL6 CASP3 CCDC24 CEBPE CHRD CREBBP DGCR6L DNMT3L FANCG FANCL FBF1 FHL3 FLI1 FRS3 GLRX3 GOLGA2 GRAP2 HDAC3 HDAC4 HDAC5 HEMGN HEXIM2 HEY1 HOXA1 HSPA4 KANK2 KRTAP10-5 KRTAP3-2 KRTAP4-11 KRTAP4-5 KRTAP9-2 LMO2 LZTS2 MAPK1 MAPK3 MAPK6 MDFI MED1 MGAT5B MKRN3 PIAS4 PITX1 PLSCR4 PML PNMA1 PPP1R16B PRKAA1 PRKAB2 PSMF1 RADIL RAI1 RBPMS RIN3 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SP1 SPI1 SPIB SRA1 STAT3 TAF7 TAL1 TAX1BP3 TEKT4 TLE5 TNS2 TRAF1 TRIM25 TRIM29 TRIP6 USP7 ZBTB16 ZBTB22 ZDHHC17 ZFPM1 ZFPM2 ZNF521 ZZZ3
Entrez ID		23414	2623
HPRD ID		04737	02372
Ensembl ID		ENSG00000169946	ENSG00000102145
Uniprot IDs		E7ET52 Q8WW38 Q9NPQ0	P15976
PDB IDs			6G0Q
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Coregulator Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Cell Fate Commitment Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Autophagy Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Male Gonad Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Gonad Development Negative Regulation Of Metabolic Process Transcription Coactivator Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Reproductive Structure Development Transcription Repressor Complex Identical Protein Binding Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Developmental Process Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Chromatin DNA Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T-helper 17 Cell Lineage Commitment Transcription Cis-regulatory Region Binding Cardiac Right Ventricle Morphogenesis Nucleic Acid Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA White Fat Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process T-helper Cell Lineage Commitment Chromatin Viral Genome Replication DNA-binding Transcription Factor Activity CD4-positive, Alpha-beta T Cell Lineage Commitment Fat Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulator Complex Platelet Formation Alpha-beta T Cell Lineage Commitment Embryonic Hemopoiesis	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process NpBAF Complex NBAF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleosome Disassembly Regulation Of G0 To G1 Transition Protein-DNA Complex Disassembly Transcription Coactivator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Brahma Complex RSC-type Complex Regulation Of Nucleotide-excision Repair SWI/SNF Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process BBAF Complex Protein Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA Metabolic Process Positive Regulation Of Double-strand Break Repair DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Lymphocyte Differentiation Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Myoblast Differentiation Nucleoplasm Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Regulation Of Double-strand Break Repair Regulation Of Myoblast Differentiation Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of T Cell Differentiation Chromatin Remodeling
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