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LMAN2 and FRAT1
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
LMAN2
FRAT1
Gene Name
lectin, mannose-binding 2
frequently rearranged in advanced T-cell lymphomas 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Extracellular Space
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Golgi Apparatus
Integral Component Of Plasma Membrane
Cell Surface
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Extracellular Vesicular Exosome
Cytosol
Molecular Function
Glycoprotein Binding
Mannose Binding
Carbohydrate Binding
Heat Shock Protein Binding
Metal Ion Binding
Biological Process
Retrograde Vesicle-mediated Transport, Golgi To ER
Protein Transport
Positive Regulation Of Phagocytosis
Embryonic Axis Specification
Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
misspliced GSK3beta mutants stabilize beta-catenin
APC truncation mutants have impaired AXIN binding
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
RNF mutants show enhanced WNT signaling and proliferation
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
XAV939 inhibits tankyrase, stabilizing AXIN
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
deletions in the AMER1 gene destabilize the destruction complex
TCF dependent signaling in response to WNT
AMER1 mutants destabilize the destruction complex
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Activated partial thromboplastin time (
22703881
)
Chronic kidney disease (
20383146
)
Protein-Protein Interactions
4 interactors:
ATP13A2
FRAT1
MAPK9
SUPT5H
13 interactors:
DVL1
GPRASP2
GRN
GSK3B
KCNK5
KRT18
LAMC3
LMAN2
LTBP4
PLSCR1
PSMA3
RABEP2
TDRD7
Entrez ID
10960
10023
HPRD ID
17285
03935
Ensembl ID
ENSG00000169223
ENSG00000165879
Uniprot IDs
Q12907
Q92837
PDB IDs
1GNG
3ZRK
3ZRL
3ZRM
4AFJ
Enriched GO Terms of Interacting Partners
?
Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Cellular Response To Manganese Ion
JUN Phosphorylation
Positive Regulation Of Prostaglandin Biosynthetic Process
Response To Metal Ion
Positive Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of Prostaglandin Secretion
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Response To Inorganic Substance
Positive Regulation Of Macroautophagy
Response To Manganese Ion
Negative Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of Icosanoid Secretion
Positive Regulation Of Fatty Acid Transport
Viral Genome Replication
Positive Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Release Of Cytochrome C From Mitochondria
Positive Regulation Of Fatty Acid Metabolic Process
7-methylguanosine MRNA Capping
Regulation Of Fatty Acid Transport
Regulation Of Fatty Acid Biosynthetic Process
Protein Localization To Microtubule
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Protein Localization To Cytoskeleton
Positive Regulation Of Cellular Protein Catabolic Process
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteolysis
Negative Regulation Of Protein Binding
Positive Regulation Of Proteolysis
Negative Regulation Of Transferase Activity
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Golgi To Plasma Membrane CFTR Protein Transport
Positive Regulation Of Proteasomal Protein Catabolic Process
Transport
Regulation Of Protein Catabolic Process
Negative Regulation Of Type B Pancreatic Cell Development
Superior Temporal Gyrus Development
Apoptotic Process
Canonical Wnt Signaling Pathway
Negative Regulation Of Binding
Programmed Cell Death
Extrinsic Apoptotic Signaling Pathway
Cell Death
Death
Convergent Extension Involved In Neural Plate Elongation
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Re-entry Into Mitotic Cell Cycle
Negative Regulation Of Neuron Maturation
Protein Localization
Establishment Of Localization In Cell
Hypermethylation Of CpG Island
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Binding
Collateral Sprouting
Cellular Response To Interleukin-3
Sensory Organ Development
Phosphatidylserine Biosynthetic Process
Convergent Extension Involved In Organogenesis
Negative Regulation Of Glycogen (starch) Synthase Activity
Regulation Of Neuron Maturation
Protein Transport
Regulation Of Catalytic Activity
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Dendrite Morphogenesis
Tagcloud
?
apc
axin1
cadherin
catenin
ck1
colon
destruction
du145
elucidate
emt
gsk3beta
ht29
inhibiting
involves
localization
maintaining
mesenchymal
modulate
ndrg1
pak4
precise
prevents
ser33
thr41
transforming
translocation
transporter
upregulation
wnt
Tagcloud (Difference)
?
apc
axin1
cadherin
catenin
ck1
colon
destruction
du145
elucidate
emt
gsk3beta
ht29
inhibiting
involves
localization
maintaining
mesenchymal
modulate
ndrg1
pak4
precise
prevents
ser33
thr41
transforming
translocation
transporter
upregulation
wnt
Tagcloud (Intersection)
?