IFRD2 and OAS3

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IFRD2	OAS3
Description		interferon related developmental regulator 2	2'-5'-oligoadenylate synthetase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Translation Repressor Activity Ribosome Binding	Nucleotide Binding 2'-5'-oligoadenylate Synthetase Activity RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding
	Biological Process	Regulation Of Translation Wnt Signaling Pathway Negative Regulation Of Translation Fat Cell Differentiation Adipose Tissue Development	Immune System Process Nucleobase-containing Compound Metabolic Process Response To Virus Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Chemokine (C-X-C Motif) Ligand 9 Production RIG-I Signaling Pathway MDA-5 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Ribonuclease Activity Interleukin-27-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of IP-10 Production Defense Response To Other Organism Antiviral Innate Immune Response Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways			Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Body mass index ( 26426971) Chronic lymphocytic leukemia ( 28165464) HDL cholesterol ( 21909109) High density lipoprotein cholesterol levels ( 30718733) Hypertension ( 32709000) Low HDL-cholesterol levels ( 31006500) Myocardial infarction ( 30226566) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239)
Interacting Genes		8 interacting genes: APP JRK MDFI NEDD4L OAS3 OGT POT1 UBE2O	6 interacting genes: DHX30 EIF6 FTSJ3 IFRD2 MAVS RNF10
Entrez ID		7866	4940
HPRD ID		04101	04519
Ensembl ID		ENSG00000214706	ENSG00000111331
Uniprot IDs		Q12894	A0A7P0T8S7 Q9Y6K5
PDB IDs			4S3N
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Regulation Of Wnt Signaling Pathway Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Synapse Organization Positive Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of Chemokine (C-X-C Motif) Ligand 9 Production Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Monoubiquitination Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Negative Regulation Of Macromolecule Biosynthetic Process Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Negative Regulation Of Biosynthetic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Positive Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Low-density Lipoprotein Particle Mediated Signaling Regulation Of Signaling MDA-5 Signaling Pathway Negative Regulation Of IP-10 Production Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production 2'-5'-oligoadenylate Synthetase Activity	Maturation Of 5.8S RRNA Ribonucleoprotein Complex Biogenesis Ribosome Biogenesis Maturation Of LSU-rRNA Assembly Of Large Subunit Precursor Of Preribosome Ribosome Binding Positive Regulation Of IP-10 Production Regulation Of Peroxisome Organization RNA 2'-O-methyltransferase Activity RRNA (uridine-2'-O-)-methyltransferase Activity Lamin Filament Cytosolic Ribosome Assembly Negative Regulation Of Translation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA (guanine) Methyltransferase Activity RRNA Methyltransferase Activity RRNA Processing Protein-RNA Complex Assembly Mitochondrial Large Ribosomal Subunit Assembly Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Negative Regulation Of Schwann Cell Proliferation G-quadruplex RNA Binding RRNA Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Ribosomal Subunit Export From Nucleus Positive Regulation Of Dendritic Cell Cytokine Production Preribosome, Small Subunit Precursor
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