MGA and E2F1

Number of citations of the paper that reports this interaction (PubMedID 12748276)
56

Data Source:
BioGRID (two hybrid)

		MGA	E2F1
Description		MAX dimerization protein MGA	E2F transcription factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Protein-containing Complex MLL1 Complex	Nuclear Chromosome Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Protein-containing Complex Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Sequence-specific DNA Binding Protein Dimerization Activity Molecular Adaptor Activity DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription	DNA Damage Checkpoint Signaling Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Forebrain Development Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Anoikis Negative Regulation Of DNA Binding Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation MRNA Stabilization Regulation Of Cell Cycle Positive Regulation Of Glial Cell Proliferation Negative Regulation Of Fat Cell Proliferation Cellular Response To Fatty Acid Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Lens Fiber Cell Apoptotic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Transcriptional Regulation by E2F6	Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest G2 Phase Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS		Feeling nervous ( 29500382) Lung function (FEV1/FVC) ( 28166213 30804560) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Heel bone mineral density ( 30598549) Height ( 31562340) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: CBX3 E2F1 E2F3 E2F4 H3-4 LSM8 MAX SMAD1 TULP3	83 interacting genes: ARID3A ATAD2 ATM ATR BIN1 BIRC2 BRCA1 BRD2 BRMS1 BTRC CCNA1 CCNA2 CCNF CDK1 CDK2 CDK3 CDK7 CDKN2A CEBPE CHEK2 CREBBP CTDP1 CUL1 CUL2 DDB2 DIABLO E2F6 EP300 ERCC3 FHL2 GSK3B GTF2H1 HCFC1 IGF1 KAT5 KDM1A MDM4 MGA MNAT1 MTA1 MYBL2 NCOA3 NCOA6 NCOR2 NDN NFKB1 NPDC1 NRIP1 NSMCE3 PARP1 PHB1 PKIB PRDM2 PURA RARA RB1 RBL1 RNF126 RNF144A SERTAD2 SETD7 SIRT1 SKP2 SP1 SP2 SP3 SP4 SPIB STAT1 STOML1 SZRD1P1 TBP TEAD3 TFDP1 TFDP2 TOPBP1 TP53 TP53BP1 TRRAP UBE3A UCHL5 VHL YWHAQ
Entrez ID		23269	1869
HPRD ID		19055	01806
Ensembl ID		ENSG00000174197	ENSG00000101412
Uniprot IDs		A0A994J6L2 Q8IWI9	Q01094 Q9BSD8
PDB IDs			1H24 1O9K 2AZE 5M9N 5M9O 6G0P 6ULS 9CB3
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Activator Activity Protein Dimerization Activity Negative Regulation Of Fat Cell Proliferation Transcription Regulator Complex Chromatin Nucleoplasm DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Nuclear Inner Membrane Heterochromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Bone Development Regulation Of RNA Metabolic Process Nucleus Regulation Of Primary Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Homomeric SMAD Protein Complex Myc-Max Complex Mad-Max Complex Bronchus Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Intraciliary Transport Particle A Binding Chromatin Lock Complex Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Lens Fiber Cell Apoptotic Process Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Spermatogonial Cell Division Senescence-associated Heterochromatin Focus Regulation Of Macromolecule Metabolic Process Rb-E2F Complex Anti-Mullerian Hormone Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process Chromatin Organization DNA Damage Response Chromatin Remodeling Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Repair G1/S Transition Of Mitotic Cell Cycle DNA Metabolic Process Cell Cycle G1/S Phase Transition Chromatin Cellular Response To Stress Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Protein Localization To Site Of Double-strand Break Positive Regulation Of DNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Programmed Cell Death
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