Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
PSME4 and CALCOCO2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
PSME4
CALCOCO2
Gene Name
proteasome (prosome, macropain) activator subunit 4
calcium binding and coiled-coil domain 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytosol
Nuclear Speck
Spermatoproteasome Complex
Nucleus
Cytoplasm
Golgi Apparatus
Cytoskeleton
Membrane
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
Molecular Function
Peptidase Activator Activity
Lysine-acetylated Histone Binding
Protein Binding
Protein Homodimerization Activity
Biological Process
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
DNA Repair
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Multicellular Organismal Development
Gene Expression
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Peptidase Activity
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Spermatogenesis, Exchange Of Chromosomal Proteins
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Viral Process
Response To Interferon-gamma
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
Cell Cycle Checkpoints
degradation of DVL
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
M Phase
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions
2 interactors:
CALCOCO2
NUTM1
143 interactors:
ABLIM1
ADSL
AES
AKAP17A
AMMECR1
AP5B1
APEX2
ARHGEF39
ARHGEF5
ARNT2
BAHD1
BCL6B
BEX2
C20orf195
CBX8
CCDC185
CCDC33
CCNH
CEP57L1
CHCHD3
CPNE7
CWF19L2
DAXX
DAZAP2
DBNDD2
DCTN4
DCX
DDIT4L
DDX6
DOCK2
DUSP12
DUSP26
EEF1E1
ENKD1
EXOSC5
FAM107A
FAM161A
FAM168A
FAM189A2
FAM90A1
FARS2
FASTK
FBF1
FBXL18
FKBPL
FXR2
GABARAPL1
GABARAPL2
GATAD2B
GEMIN4
GIT2
GLYCTK
HDAC7
HOXB9
IKBKG
KANSL1
KAT7
KLHL42
LENG1
LGALS8
LIMS2
LITAF
LMF2
LMO2
LMO4
LNX1
LONRF1
LSM4
MAGOHB
MAVS
MCM10
METTL17
MID2
MOS
MTPAP
MVP
MXI1
MYO6
NAA10
NDN
NFU1
ORC5
PAPD4
PCGF1
PEF1
PEG10
PFDN5
PHF1
PIAS4
POLI
PPP1R18
PRKAB2
PRPF31
PSMA1
PSME4
PTBP1
PTBP2
RABL6
RB1CC1
RBM15
RHPN1
RIN1
RNF11
RPA2
RPL9
RPS27A
RTN4IP1
RTP5
SDCBP
SHC1
SLC15A3
SMARCD1
SMCP
SNRPB
SPATA24
SRI
STK16
TAX1BP1
TBC1D22B
TBK1
TBRG4
TCEB3B
TCL1A
TEKT3
TP53RK
TRAF2
TRAF4
TRAF6
UBAC2
UBB
UBC
VARS
VPS72
ZC2HC1C
ZNF101
ZNF205
ZNF337
ZNF408
ZNF426
ZNF451
ZNF564
ZNF581
ZNF638
Entrez ID
23198
10241
HPRD ID
09652
06846
Ensembl ID
ENSG00000068878
ENSG00000136436
Uniprot IDs
Q14997
Q13137
PDB IDs
3VVV
3VVW
4GXL
4HAN
Enriched GO Terms of Interacting Partners
?
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
I-kappaB Kinase/NF-kappaB Signaling
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Cellular Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Type I Interferon Production
MRNA Metabolic Process
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
JNK Cascade
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Protein Modification By Small Protein Conjugation
Activation Of MAPK Activity
Activation Of Innate Immune Response
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Positive Regulation Of Protein Modification Process
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Type I Interferon Production
Activation Of NF-kappaB-inducing Kinase Activity
Protein Ubiquitination
Toll-like Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Mitotic G1 DNA Damage Checkpoint
Tagcloud
?
ad
astrocytes
atg
atgs
autophagic
autophagy
avs
beneficial
brains
clear
clearance
enhancement
expected
facilitating
flux
hippocampal
impairment
lc3
localized
microglia
mouse
ndp52
p62
phosphorylated
plaques
reflecting
sqstm1
tau
vesicles
Tagcloud (Difference)
?
ad
astrocytes
atg
atgs
autophagic
autophagy
avs
beneficial
brains
clear
clearance
enhancement
expected
facilitating
flux
hippocampal
impairment
lc3
localized
microglia
mouse
ndp52
p62
phosphorylated
plaques
reflecting
sqstm1
tau
vesicles
Tagcloud (Intersection)
?