METAP1 and RBM11

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		METAP1	RBM11
Description		methionyl aminopeptidase 1	RNA binding motif protein 11
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytosolic Ribosome	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Aminopeptidase Activity Initiator Methionyl Aminopeptidase Activity Protein Binding Peptidase Activity Metalloexopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding Protein Binding Poly(U) RNA Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Translation Proteolysis Protein Maturation Platelet Aggregation	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cell Differentiation Cellular Response To Oxidative Stress
Pathways		Inactivation, recovery and regulation of the phototransduction cascade
Drugs		Ovalicin 5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE TERT-BUTYL {2-[(1,3-THIAZOL-2-YLAMINO)CARBONYL]PYRIDIN-3-YL}CARBAMATE 3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Alcohol dependence ( 33290381) Alcohol use disorder (consumption score) ( 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Oral cavity and pharyngeal cancer ( 27749845) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		8 interacting genes: DSCAM GLRX3 INCA1 MEOX2 NBR1 PLEKHG4 RBM11 SMAD9	78 interacting genes: ACOT1 APP ATIC ATOSB ATRX BHLHE40 CEP85 CERCAM CHCHD3 CHD6 CNTNAP1 COPA CRYAB DALRD3 DAZAP2 DCAF8 DDX27 DDX6 DST DTX2 EDIL3 ENKD1 FN3K GABPB1 GADD45GIP1 GLIS2 GPATCH2L HERPUD2 HMG20A LRP1 MADD MAN1A2 MECOM MED13L METAP1 MYO15B NEFL NMT2 PCBP1 PCM1 PCYT1A PDHB PIBF1 PLCG1 PLEKHB1 POLG PRRC2A PSMD4 QKI RBFOX3 RHOXF2 RNF38 SAXO4 SCNM1 SCYL2 SF3B2 SNRNP70 SNRPA SNRPC SPRED1 STAMBP TUBB4A U2AF2 VIM ZCCHC8 ZFHX3 ZKSCAN5 ZMYND10 ZNF189 ZNF214 ZNF251 ZNF302 ZNF329 ZNF414 ZNF606 ZNF7 ZNF774 ZNF83
Entrez ID		23173	54033
HPRD ID		10071	10185
Ensembl ID		ENSG00000164024	ENSG00000185272
Uniprot IDs		P53582	P57052
PDB IDs		2B3H 2B3K 2B3L 2G6P 2GZ5 2NQ6 2NQ7 4FLI 4FLJ 4FLK 4FLL 4HXX 4IKR 4IKS 4IKT 4IKU 4IU6 4U1B 4U69 4U6C 4U6E 4U6J 4U6W 4U6Z 4U70 4U71 4U73 4U75 4U76 5YKP 5YR4 5YR5 5YR6 5YR7 6LZB 6LZC 8P2K 9F1C 9F1D 9FQ0	2YWK
Enriched GO Terms of Interacting Partners?			Nucleus RNA Splicing, Via Transesterification Reactions U1 SnRNA Binding MRNA Splicing, Via Spliceosome DNA Binding Spliceosomal Complex Zinc Ion Binding RNA Splicing Metal Ion Binding Nucleic Acid Binding U2-type Prespliceosome U1 SnRNP Regulation Of RNA Metabolic Process Astrocyte Activation Involved In Immune Response MRNA Binding MRNA Processing Commitment Complex Microtubule-based Process Stress Granule Assembly U1 SnRNP Binding
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