EXPH5 and RAB27A

Number of citations of the paper that reports this interaction (PMID 11773082)
41

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		EXPH5	RAB27A
Gene Name		exophilin 5	RAB27A, member RAS oncogene family
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome	Photoreceptor Outer Segment Lysosome Late Endosome Golgi Apparatus Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Melanosome Extracellular Vesicular Exosome Exocytic Vesicle
	Molecular Function	Rab GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Keratinocyte Development Intracellular Protein Transport Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway	Protein Targeting Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways			Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: APC RAB27A SMAD9	28 interactors: ADRB2 APP C14orf1 COPS6 EEF1A1 EXPH5 GDF9 GDI1 GZMB KIAA1377 LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		23086	5873
HPRD ID		08341	04845
Ensembl ID		ENSG00000110723	ENSG00000069974
Uniprot IDs		E9PC93 Q149M6 Q8NEV8	A2RU94 P51159
PDB IDs
Enriched GO Terms of Interacting Partners?		Epithelium Development Positive Regulation Of Constitutive Secretory Pathway Complement-dependent Cytotoxicity Multivesicular Body Organization Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cytotoxic T Cell Degranulation Tissue Development T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Multivesicular Body Sorting Pathway Exosomal Secretion Negative Regulation Of Odontogenesis Kidney Development Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Renal System Development Natural Killer Cell Degranulation Urogenital System Development Metaphase/anaphase Transition Of Mitotic Cell Cycle Lymphocyte Activation Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Mullerian Duct Regression T Cell Mediated Cytotoxicity Leukocyte Activation Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Microtubule Polymerization Single Organismal Cell-cell Adhesion Positive Regulation Of Pseudopodium Assembly Anatomical Structure Regression Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Natural Killer Cell Activation Involved In Immune Response Cell Activation Positive Regulation Of Regulated Secretory Pathway Natural Killer Cell Mediated Cytotoxicity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Natural Killer Cell Mediated Immunity Positive Regulation Of Metabolic Process Response To Stress Muscle Cell Cellular Homeostasis Regulation Of Microtubule Polymerization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Odontogenesis T Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Cell Differentiation Melanosome Transport Endosome Organization	Exocytosis Secretion By Cell Intracellular Transport Secretion Cellular Protein Localization Establishment Of Localization In Cell Cellular Localization Protein Transport Intracellular Protein Transport Establishment Of Protein Localization Protein Localization Vesicle-mediated Transport Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Secretion Transport Positive Regulation Of Exocytosis Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Establishment Of Protein Localization Multivesicular Body Sorting Pathway Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Protein Localization Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Protein Transport Positive Regulation Of Protein Secretion Regulation Of Protein Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Vesicle Localization Regulation Of Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Hormone Secretion Neurotransmitter Secretion Regulation Of Signaling Membrane Depolarization Glutamate Secretion Positive Regulation Of Protein Transport Regulation Of Neurotransmitter Levels Membrane Hyperpolarization Melanocyte Differentiation Neurotransmitter Transport Melanosome Localization Visual Perception Sensory Perception Of Light Stimulus Insulin Secretion Organelle Localization
Tagcloud ?		archive bcl6 cancerous cebpb checked col1a1 col1a2 cufflinks david deg degs downloaded fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools	adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Difference) ?		archive bcl6 cebpb checked col1a1 col1a2 cufflinks david deg degs downloaded fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools	adenocarcinoma aggressive benign carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Intersection) ?		cancerous