SWAP70 and RAPGEF4

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		SWAP70	RAPGEF4
Gene Name		SWAP switching B-cell complex 70kDa subunit	Rap guanine nucleotide exchange factor (GEF) 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Lamellipodium	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane
	Molecular Function	DNA Binding Calcium Ion Binding ATP Binding	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Ras GTPase Binding CAMP Binding
	Biological Process	Isotype Switching	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Calcium Ion-dependent Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Platelet Activation Positive Regulation Of Ras GTPase Activity Small Molecule Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion
Pathways			Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Integration of energy metabolism Regulation of insulin secretion Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CELSR3 IGHG1 PARP1 RAPGEF4 ZBTB5	11 interactors: ATXN1 BZRAP1 C16orf45 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 ZC3H11A
Entrez ID		23075	11069
HPRD ID		10378	06929
Ensembl ID		ENSG00000133789	ENSG00000091428
Uniprot IDs		E7EMB1 Q9UH65	B7Z283 Q8WZA2
PDB IDs		2DN6
Enriched GO Terms of Interacting Partners?			Rap Protein Signal Transduction Ras Protein Signal Transduction Negative Regulation Of Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Intracellular Signal Transduction Neurotransmitter Secretion Membrane Depolarization Nuclear Export Regulation Of Neurotransmitter Levels Synaptic Transmission Regulation Of Phosphorylation Regulation Of Cell Migration Regulation Of Exocytosis Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Regulation Of JNK Cascade Regulation Of Cell Motility Neurotransmitter Transport Regulation Of Secretion Cellular Localization Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Stress-activated MAPK Cascade Regulation Of Locomotion Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Movement Regulation Of Neurogenesis Negative Regulation Of Cell Migration Positive Regulation Of Protein Phosphorylation Calcium Ion-dependent Exocytosis Of Neurotransmitter Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Motility Positive Regulation Of Protein Homodimerization Activity Negative Regulation Of Cellular Component Movement
Tagcloud ?			adenylyl analog calr calreticulin camp chlorophenylthio cox2 cpt cyclase cyclooxygenase em1 endometrial epac epac2 establishment forskolin galactosidase glands glandular implantation lif pge2 phe pka prostaglandin ptgs2 receptivity silenced uterine
Tagcloud (Difference) ?			adenylyl analog calr calreticulin camp chlorophenylthio cox2 cpt cyclase cyclooxygenase em1 endometrial epac epac2 establishment forskolin galactosidase glands glandular implantation lif pge2 phe pka prostaglandin ptgs2 receptivity silenced uterine
Tagcloud (Intersection) ?