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SWAP70
Description
switching B cell complex subunit SWAP70
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Actin Cytoskeleton
Membrane
Lamellipodium
Cell Projection
Postsynapse
Molecular Function
DNA Binding
Guanyl-nucleotide Exchange Factor Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Cadherin Binding
Biological Process
Positive Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Actin Polymerization Or Depolymerization
Somatic Cell DNA Recombination
Negative Regulation Of Actin Filament Depolymerization
Positive Regulation Of Actin Filament Bundle Assembly
Regulation Of Protein Localization
Negative Regulation Of Cell-cell Adhesion Mediated By Integrin
Isotype Switching
Actin Filament Bundle Assembly
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Mast Cell Chemotaxis
Pathways
RAC1 GTPase cycle
RAC2 GTPase cycle
RAC3 GTPase cycle
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Coronary artery disease (
26343387
33020668
32469254
29212778
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Diastolic blood pressure (
27841878
30487518
30224653
28739976
)
hemolysis of donated blood (osmotic) (
34014839
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Hypertension (
30487518
)
Mean arterial pressure (
29403010
30487518
)
Mean corpuscular hemoglobin concentration (
27863252
32888494
)
Mean corpuscular volume (
29403010
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Medication use (diuretics) (
31015401
)
Myocardial infarction (
33532862
)
Platelet distribution width (
27863252
32888494
)
Plateletcrit (
32888494
)
Pulse pressure (
27841878
)
Red cell distribution width (
32888494
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Rheumatoid arthritis (
32723749
)
Systolic blood pressure (
30578418
27841878
30487518
)
White blood cell count (
32888494
)
Interacting Genes
5 interacting genes:
CELSR3
IGHG1
PARP1
RAPGEF4
ZBTB5
Entrez ID
23075
HPRD ID
10378
Ensembl ID
ENSG00000133789
Uniprot IDs
B3KUB9
E7EMB1
Q9UH65
PDB IDs
2DN6
Enriched GO Terms of Interacting Partners
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NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity
NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity
NAD+-protein-histidine ADP-ribosyltransferase Activity
NAD+-protein-tyrosine ADP-ribosyltransferase Activity
DNA ADP-ribosylation
Positive Regulation Of Myofibroblast Differentiation
Negative Regulation Of ATP Biosynthetic Process
NAD+-protein-serine ADP-ribosyltransferase Activity
NAD DNA ADP-ribosyltransferase Activity
Dopaminergic Neuron Axon Guidance
Serotonergic Neuron Axon Guidance
Complement-dependent Cytotoxicity
Fc-gamma Receptor I Complex Binding
Regulation Of Base-excision Repair
ATP Generation From Poly-ADP-D-ribose
Transcription Pausing By RNA Polymerase II
Replication Fork Reversal
Positive Regulation Of Necroptotic Process
Mitochondrial DNA Repair
Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
Negative Regulation Of Adipose Tissue Development
Antibody-dependent Cellular Cytotoxicity
Immunoglobulin Complex, Circulating
Regulation Of Myofibroblast Differentiation
Positive Regulation Of Mitochondrial Depolarization
IgG Immunoglobulin Complex
Immune Response
Protein Auto-ADP-ribosylation
Positive Regulation Of Programmed Necrotic Cell Death
Transcription Regulator Activator Activity
Adaptive Immune Response
Hypersensitivity
NAD+-protein-glutamate ADP-ribosyltransferase Activity
Positive Regulation Of Membrane Depolarization
Positive Regulation Of Adipose Tissue Development
NAD+-protein-aspartate ADP-ribosyltransferase Activity
Tagcloud
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