SWAP70 and ZBTB5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SWAP70	ZBTB5
Description		switching B cell complex subunit SWAP70	zinc finger and BTB domain containing 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Lamellipodium Cell Projection Postsynapse	Chromatin Nucleus
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding ATP Binding Cadherin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Actin Polymerization Or Depolymerization Somatic Cell DNA Recombination Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Protein Localization Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Isotype Switching Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Mast Cell Chemotaxis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 26343387 33020668 32469254 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878 30487518 30224653 28739976) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Rheumatoid arthritis ( 32723749) Systolic blood pressure ( 30578418 27841878 30487518) White blood cell count ( 32888494)	Bipolar disorder ( 31043756) Daytime nap ( 33568662)
Interacting Genes		5 interacting genes: CELSR3 IGHG1 PARP1 RAPGEF4 ZBTB5	17 interacting genes: BAG4 BCOR CCDC85B DCX EP300 JADE2 METTL5 NCOR1 NCOR2 PPARG PTPN5 RSPH1 SP1 ST3GAL3 SWAP70 TP53 ZBTB7B
Entrez ID		23075	9925
HPRD ID		10378	08829
Ensembl ID		ENSG00000133789	ENSG00000168795
Uniprot IDs		B3KUB9 E7EMB1 Q9UH65	O15062 Q5T942
PDB IDs		2DN6	9B9R
Enriched GO Terms of Interacting Partners?		NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity DNA ADP-ribosylation Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of ATP Biosynthetic Process NAD+-protein-serine ADP-ribosyltransferase Activity NAD DNA ADP-ribosyltransferase Activity Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Regulation Of Base-excision Repair ATP Generation From Poly-ADP-D-ribose Transcription Pausing By RNA Polymerase II Replication Fork Reversal Positive Regulation Of Necroptotic Process Mitochondrial DNA Repair Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Adipose Tissue Development Antibody-dependent Cellular Cytotoxicity Immunoglobulin Complex, Circulating Regulation Of Myofibroblast Differentiation Positive Regulation Of Mitochondrial Depolarization IgG Immunoglobulin Complex Immune Response Protein Auto-ADP-ribosylation Positive Regulation Of Programmed Necrotic Cell Death Transcription Regulator Activator Activity Adaptive Immune Response Hypersensitivity NAD+-protein-glutamate ADP-ribosyltransferase Activity Positive Regulation Of Membrane Depolarization Positive Regulation Of Adipose Tissue Development NAD+-protein-aspartate ADP-ribosyltransferase Activity	Histone Deacetylase Binding Rhythmic Process Transcription Repressor Complex Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Transcription Coregulator Binding Nuclear Receptor Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Carbohydrate Catabolic Process STAT Family Protein Binding Regulation Of RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Purine Nucleotide Metabolic Process Nuclear Retinoid X Receptor Binding Negative Regulation Of Androgen Receptor Signaling Pathway Host-mediated Activation Of Viral Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitochondrion Organization Negative Regulation Of Small Molecule Metabolic Process Circadian Behavior Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Rhythmic Behavior Mononuclear Cell Differentiation Histone Acetyltransferase Complex Regulation Of Small Molecule Metabolic Process Regulation Of Ketone Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Circadian Rhythm Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Fat Cell Differentiation Regulation Of T-helper 17 Cell Differentiation Host-mediated Perturbation Of Viral Transcription Regulation Of Primary Metabolic Process Chromatin Positive Regulation Of Apoptotic Signaling Pathway DNA Binding T Cell Lineage Commitment Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Leukocyte Differentiation
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