FOXM1 and USP21

Number of citations of the paper that reports this interaction (PubMedID 30865895)
57

Data Source:
BioGRID (enzymatic study)

		FOXM1	USP21
Description		forkhead box M1	ubiquitin specific peptidase 21
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Sequence-specific DNA Binding	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Cell Cycle Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Double-strand Break Repair	Chromatin Organization Proteolysis Protein Deubiquitination Ribosome Disassembly Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Rescue Of Stalled Ribosome
Pathways		Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition Nuclear events stimulated by ALK signaling in cancer	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS		Height ( 31562340)
Interacting Genes		22 interacting genes: BANP CCNE1 CDK1 CDK2 CDK4 CDK6 CHEK2 CREBBP DCAF1 LINC00857 MTDH OS9 RB1 RNF112 SIRT1 STAT3 SUMO1 UBE2I UCHL3 USP21 USP7 ZBTB3	65 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CDC34 CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXD1 FOXM1 H2AC18 H2BC3 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RIPK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2D1 UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 YY1 ZNF350
Entrez ID		2305	27005
HPRD ID		03823	05291
Ensembl ID		ENSG00000111206	ENSG00000143258
Uniprot IDs		A0A0D9SFF0 A0A2P9DTZ0 A0A2P9DTZ1 A0A2P9DTZ8 A8K591 Q08050 Q53Y49	Q9UK80
PDB IDs		3G73 7FJ2	2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Mitotic Cell Cycle Phase Transition Protein Modification Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex PML Body Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Cyclin Binding Protein Modification By Small Protein Conjugation Regulation Of Mitotic Cell Cycle DNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Deubiquitination Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Nuclear Body Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Protein Modification By Small Protein Removal Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Chromatin Remodeling Protein Metabolic Process Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA Repair Nucleus Regulation Of Primary Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Response Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Catabolic Process Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity	Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification Process Protein Deubiquitination Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Proteolysis Protein Metabolic Process Peptidase Activity Macromolecule Metabolic Process Protein K48-linked Deubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Deubiquitinase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Cysteine-type Endopeptidase Activity Ubiquitin Protein Ligase Activity Protein K63-linked Deubiquitination Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Catabolic Process K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Protein Polyubiquitination Hydrolase Activity Ubiquitin Protein Ligase Binding Monoubiquitinated Protein Deubiquitination Regulation Of Cellular Response To Stress Ubiquitin Binding TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process TOR Signaling Response To Stress Nucleoplasm DeNEDDylase Activity DNA Damage Response Zinc Ion Binding Negative Regulation Of TOR Signaling Regulation Of Protein Stability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Regulation Of Intracellular Signal Transduction DNA Repair Regulation Of Telomere Maintenance Positive Regulation Of Autophagy Negative Regulation Of Intracellular Signal Transduction
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