FOXJ1 and FKBP1A

		FOXJ1	FKBP1A
Description		forkhead box J1	FKBP prolyl isomerase 1A
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Cytosol Terminal Cisterna Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Cytoplasmic Side Of Membrane Ryanodine Receptor Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Transforming Growth Factor Beta Receptor Binding Calcium Channel Regulator Activity Protein Binding Macrolide Binding FK506 Binding Isomerase Activity Signaling Receptor Inhibitor Activity Type I Transforming Growth Factor Beta Receptor Binding Transmembrane Transporter Binding I-SMAD Binding Activin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Central Tolerance Induction Negative Regulation Of Germinal Center Formation Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Brain Development Heart Development Intracellular Protein Localization Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Epithelial Cell Differentiation Ciliary Basal Body Organization Negative Regulation Of Interleukin-6 Production Negative Regulation Of T Cell Differentiation In Thymus Axoneme Assembly Establishment Of Apical/basal Cell Polarity Metanephric Part Of Ureteric Bud Development Negative Regulation Of T Cell Proliferation Motile Cilium Assembly Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Negative Regulation Of B Cell Activation Leukocyte Migration Cilium Assembly Lung Epithelium Development Epithelium Development Left/right Pattern Formation Glomerular Parietal Epithelial Cell Development Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Lung Ciliated Cell Differentiation	Heart Morphogenesis Protein Folding 'de Novo' Protein Folding Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization Negative Regulation Of Activin Receptor Signaling Pathway Protein Refolding T Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Protein Maturation Ventricular Cardiac Muscle Tissue Morphogenesis Heart Trabecula Formation Supramolecular Fiber Organization Regulation Of Amyloid Precursor Protein Catabolic Process Amyloid Fibril Formation
Pathways			mTORC1-mediated signalling Calcineurin activates NFAT Calcineurin activates NFAT TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR1 LBD Mutants in Cancer Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses
Drugs			Pimecrolimus Tacrolimus (3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid Gpi-1046 Methyl Methylsulfinylmethyl Sulfide FKB-001 Heptyl glucoside L-709,587 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine 4-hydroxybutan-2-one GPI-1485 Myristic acid (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE Dorsomorphin
Diseases
GWAS			Estimated glomerular filtration rate ( 31152163)
Interacting Genes		8 interacting genes: NMRAL1 OIP5 RFX2 RPUSD1 SLC37A3 THRA TRMT6 TWF2	31 interacting genes: ABI2 ACVR1B ACVRL1 AHSP APP BARD1 BMPR1A CDC42 DCAF11 DHFR ERBB2 ERBB3 ERBB4 FKBP4 GLMN HSP90AA1 ITPR1 MAPT MDM2 MID1 MTOR NLGN3 PPP3CA RYR1 RYR3 SF3B4 TGFB1 TGFB1I1 TGFBR1 TRPC3 YY1
Entrez ID		2302	2280
HPRD ID		03798	01741
Ensembl ID		ENSG00000129654	ENSG00000088832
Uniprot IDs		Q92949	A0A087WTS4 P62942 Q0VDC6
PDB IDs			1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 2DG3 2DG4 2DG9 2FAP 2FKE 2ND5 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX 4N19 4ODP 4ODQ 4ODR 5I7P 5I7Q 6I1S 6M4U 6OQA 6VCU 6YF0 6YF1 6YF2 6YF3 7EPD 7U0T 7U8D 8CHI 8CHJ 8CHK 8CHL 8CHM 8ER6 8ER7 8ERA 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD4 8JGA 8PDF 8POD 8PPZ 8X6P 8XI9 9CHU 9CHV 9CHX
Enriched GO Terms of Interacting Partners?			Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Growth Positive Regulation Of Multicellular Organismal Process Heart Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Developmental Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Projection Organization Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Differentiation Cell Development SMAD Binding Regulation Of Developmental Process Regulation Of Cell Growth Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Component Organization Transforming Growth Factor Beta Receptor Activity, Type I Receptor Complex Ubiquitin Protein Ligase Binding Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process System Development Positive Regulation Of Lamellipodium Assembly Regulation Of Cell Communication Activin Receptor Activity, Type I Regulation Of Signaling Cellular Component Assembly Signal Transduction Regulation Of Cell Differentiation Regulation Of Superoxide Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Regulation Of Epithelial Cell Proliferation Positive Regulation Of Growth Regulation Of Supramolecular Fiber Organization Negative Regulation Of Gene Expression Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction
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