FOXJ1 and GATA6

		FOXJ1	GATA6
Description		forkhead box J1	GATA binding protein 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Sequence-specific DNA Binding Metal Ion Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Central Tolerance Induction Negative Regulation Of Germinal Center Formation Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Brain Development Heart Development Intracellular Protein Localization Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Epithelial Cell Differentiation Ciliary Basal Body Organization Negative Regulation Of Interleukin-6 Production Negative Regulation Of T Cell Differentiation In Thymus Axoneme Assembly Establishment Of Apical/basal Cell Polarity Metanephric Part Of Ureteric Bud Development Negative Regulation Of T Cell Proliferation Motile Cilium Assembly Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Negative Regulation Of B Cell Activation Leukocyte Migration Cilium Assembly Lung Epithelium Development Epithelium Development Left/right Pattern Formation Glomerular Parietal Epithelial Cell Development Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Lung Ciliated Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Liver Development Sebaceous Gland Cell Differentiation Regulation Of Antimicrobial Humoral Response Outflow Tract Septum Morphogenesis Atrioventricular Node Development Sinoatrial Node Development Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phospholipid Metabolic Process Endodermal Cell Fate Determination Male Gonad Development Response To Xenobiotic Stimulus Anatomical Structure Morphogenesis Gene Expression Regulation Of Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Cell Differentiation Epithelial Cell Differentiation Pancreas Development Response To Retinoic Acid Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta2 Production Tube Morphogenesis Endodermal Cell Differentiation Atrioventricular Canal Development Negative Regulation Of Apoptotic Process Response To Estrogen Cell Fate Commitment Positive Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Animal Organ Formation System Development Cardiac Muscle Tissue Development Stem Cell Differentiation Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Heart Contraction Lung Saccule Development Club Cell Differentiation Type II Pneumocyte Differentiation Intestinal Epithelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation G1 To G0 Transition Involved In Cell Differentiation Response To Growth Factor Cellular Response To Gonadotropin Stimulus Cellular Response To Hypoxia Cellular Response To BMP Stimulus Skin Epidermis Development Positive Regulation Of Cardiac Muscle Myoblast Proliferation Negative Regulation Of Sebum Secreting Cell Proliferation
Pathways			Surfactant metabolism Cardiogenesis Formation of definitive endoderm Formation of definitive endoderm Factors involved in megakaryocyte development and platelet production Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases
GWAS			Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) LDL cholesterol ( 25961943) Lung function (FEV1/FVC) ( 30804560) Resting heart rate ( 27798624) Severe progression in rheumatoid arthritis ( 29065906) Tuberculosis ( 20694014)
Interacting Genes		8 interacting genes: NMRAL1 OIP5 RFX2 RPUSD1 SLC37A3 THRA TRMT6 TWF2	8 interacting genes: CRIP2 EP300 HHEX KLF2 KPNA3 MED1 NKX2-1 OGT
Entrez ID		2302	2627
HPRD ID		03798	09043
Ensembl ID		ENSG00000129654	ENSG00000141448
Uniprot IDs		Q92949	Q92908
PDB IDs
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Hemopoiesis Protein-DNA Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Developmental Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of RNA Metabolic Process Cellular Developmental Process Regionalization Response To Hormone Protein Localization To Organelle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Biosynthetic Process Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Cell Development Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Megakaryocyte Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Histone Acetyltransferase Complex Negative Regulation Of Metabolic Process Intracellular Protein Localization Lung Epithelial Cell Differentiation Lung Cell Differentiation DNA-binding Transcription Factor Binding Protein Localization To Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Brain Development Nuclear Receptor Binding Rhythmic Process
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