FOXD1 and USP21

Number of citations of the paper that reports this interaction (PubMedID 35974001)
44

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		FOXD1	USP21
Description		forkhead box D1	ubiquitin specific peptidase 21
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity DNA Binding, Bending Sequence-specific DNA Binding	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Metal Ion Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of BMP Signaling Pathway Luteinizing Hormone Secretion Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Dichotomous Subdivision Of Terminal Units Involved In Ureteric Bud Branching Nephrogenic Mesenchyme Development Metanephric Nephron Development Metanephric Capsule Development Metanephric Capsule Specification Pattern Specification Involved In Metanephros Development Positive Regulation Of Kidney Development	Chromatin Organization Proteolysis Protein Deubiquitination Ribosome Disassembly Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Rescue Of Stalled Ribosome
Pathways			TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045 30248107) Macular thickness ( 30535121) Monobrow ( 27182965) Monobrow thickness ( 26926045) Pulse pressure ( 30224653 30578418)
Interacting Genes		1 interacting genes: USP21	65 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CDC34 CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXD1 FOXM1 H2AC18 H2BC3 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RIPK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2D1 UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 YY1 ZNF350
Entrez ID		2297	27005
HPRD ID		03055	05291
Ensembl ID		ENSG00000251493	ENSG00000143258
Uniprot IDs		Q16676	Q9UK80
PDB IDs			2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?		DeNEDDylase Activity Positive Regulation Of Gene Expression, Epigenetic Rescue Of Stalled Ribosome Translational Elongation Ribosome Disassembly Transcription Initiation-coupled Chromatin Remodeling Cysteine-type Deubiquitinase Activity Organelle Disassembly Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity	Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification Process Protein Deubiquitination Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Proteolysis Protein Metabolic Process Peptidase Activity Macromolecule Metabolic Process Protein K48-linked Deubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Deubiquitinase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Cysteine-type Endopeptidase Activity Ubiquitin Protein Ligase Activity Protein K63-linked Deubiquitination Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Catabolic Process K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Protein Polyubiquitination Hydrolase Activity Ubiquitin Protein Ligase Binding Monoubiquitinated Protein Deubiquitination Regulation Of Cellular Response To Stress Ubiquitin Binding TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process TOR Signaling Response To Stress Nucleoplasm DeNEDDylase Activity DNA Damage Response Zinc Ion Binding Negative Regulation Of TOR Signaling Regulation Of Protein Stability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Regulation Of Intracellular Signal Transduction DNA Repair Regulation Of Telomere Maintenance Positive Regulation Of Autophagy Negative Regulation Of Intracellular Signal Transduction
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