CKAP4 and HAMP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CKAP4	HAMP
Description		cytoskeleton associated protein 4	hepcidin antimicrobial peptide
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Lipid Droplet Cytoskeleton Plasma Membrane Membrane Nuclear Speck Azurophil Granule Membrane Specific Granule Membrane Lamellar Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	RNA Binding Protein Binding	Signaling Receptor Binding Hormone Activity Iron Ion Transmembrane Transporter Inhibitor Activity Transporter Regulator Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Internalization Intracellular Iron Ion Homeostasis Immune Response Signal Transduction Response To Iron Ion Killing Of Cells Of Another Organism Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Iron Ion Transmembrane Transport Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Monoatomic Cation Homeostasis Multicellular Organismal-level Iron Ion Homeostasis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Inorganic Ion Homeostasis Positive Regulation Of Protein Polyubiquitination Iron Ion Export Across Plasma Membrane Negative Regulation Of Iron Export Across Plasma Membrane Negative Regulation Of Intestinal Absorption Positive Regulation Of Receptor Catabolic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Surfactant metabolism Neutrophil degranulation Post-translational protein phosphorylation RND3 GTPase cycle RND2 GTPase cycle
Drugs
Diseases			Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Metabolite levels ( 23823483) Refractive error ( 32231278)	Irritable bowel syndrome ( 29673008) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 28957414 32888494)
Interacting Genes		15 interacting genes: ASCC2 ATF4 DKK1 HAMP LINC01554 MLH1 MVP NDUFB7 NEIL3 NKX3-1 OGT PLAT THOC7 TSNAX WASHC3	4 interacting genes: CKAP4 GLP1R SLC40A1 VKORC1
Entrez ID		10970	57817
HPRD ID		16717	05925
Ensembl ID		ENSG00000136026	ENSG00000105697
Uniprot IDs		Q07065	P81172
PDB IDs			1M4E 1M4F 2KEF 3H0T 4QAE 6WBV
Enriched GO Terms of Interacting Partners?			Peptide Hormone Binding Glucagon-like Peptide 1 Receptor Activity Spleen Trabecula Formation Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Glucagon Receptor Activity Iron Ion Export Across Plasma Membrane Response To Psychosocial Stress Post-translational Protein Targeting To Membrane, Translocation Cellular Response To Glucagon Stimulus Activation Of Adenylate Cyclase Activity Lamellar Body Endoplasmic Reticulum Lumen Ferrous Iron Transmembrane Transporter Activity Endothelium Development Iron Ion Transmembrane Transporter Activity Cytoplasmic Exosome (RNase Complex) Exoribonuclease Complex RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Quinone Binding Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Iron Ion Transmembrane Transport RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Response To Glucagon Positive Regulation Of Cyclase Activity SnRNA 3'-end Processing Multicellular Organismal-level Iron Ion Homeostasis DNA Modification Intracellular Protein Transmembrane Transport 3'-5'-RNA Exonuclease Activity Positive Regulation Of Coagulation Positive Regulation Of Blood Pressure
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