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INSIG2
Description
insulin induced gene 2
Image
GO Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
SREBP-SCAP-Insig Complex
Molecular Function
Protein Binding
Oxysterol Binding
Lipid Binding
Protein Sequestering Activity
Biological Process
NLS-bearing Protein Import Into Nucleus
Lipid Metabolic Process
Triglyceride Metabolic Process
Cholesterol Biosynthetic Process
Response To Sterol Depletion
Steroid Metabolic Process
Cholesterol Metabolic Process
Negative Regulation Of Steroid Biosynthetic Process
Sterol Biosynthetic Process
Response To Insulin
Cellular Response To Insulin Stimulus
SREBP Signaling Pathway
Response To Lipid
SREBP-SCAP Complex Retention In Endoplasmic Reticulum
Inner Ear Morphogenesis
Middle Ear Morphogenesis
Positive Regulation Of Cholesterol Biosynthetic Process
Negative Regulation Of Fatty Acid Biosynthetic Process
Protein Maturation
Roof Of Mouth Development
Cranial Suture Morphogenesis
Response To Fatty Acid
Pathways
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Cholesterol, total (
24097068
)
Depression in response to interferon-based therapy in chronic hepatitis C (
27723809
)
Heel bone mineral density (
30598549
28869591
)
LDL cholesterol (
30275531
24097068
)
LDL cholesterol levels (
30698716
32203549
)
LDL cholesterol levels in current drinkers (
30698716
)
LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Low density lipoprotein cholesterol levels (
32154731
33339817
)
Lumbar spine bone mineral density (
22504420
)
Monobrow (
27182965
)
Mosquito bite size (
28199695
)
Total cholesterol levels (
30275531
)
Interacting Genes
55 interacting genes:
ABHD4
AQP2
AQP6
ARL13B
ATP6V0B
BIK
CD40
CD79A
CPLX4
CREB3L1
CYBC1
EBP
ELOVL4
ERGIC3
FAM209A
FAM210B
GJA8
GOLM1
GPR152
GPR37L1
GPX8
HSD17B13
IFNGR2
KIR2DL3
LAPTM5
LHFPL5
LMNA
MMGT1
MTIF3
MUC1
NEMP1
PCK1
PRLR
PSCA
PSMA7
PSMB1
PSMC3
PSMC5
PVR
RNF5
SCAP
SCN3B
SLC10A1
SLC16A10
SLC18A1
SLC35H1
SREBF2
STIM1
TMEM14B
TMEM237
TMEM45B
TMEM52B
TMX2
VCP
VMA21
Entrez ID
51141
HPRD ID
16361
Ensembl ID
ENSG00000125629
Uniprot IDs
B4DQ23
Q9Y5U4
PDB IDs
4J82
6M49
7ETW
Enriched GO Terms of Interacting Partners
?
Membrane
Endoplasmic Reticulum Membrane
Proteasome Complex
Endoplasmic Reticulum
C-8 Sterol Isomerase Activity
Positive Regulation Of Cholesterol Biosynthetic Process
Cytoplasmic Vesicle
Positive Regulation Of Cholesterol Metabolic Process
Regulation Of Cholesterol Biosynthetic Process
Proteasome-activating Activity
Positive Regulation Of Steroid Biosynthetic Process
Protein Binding
Renal Water Transport
Positive Regulation Of Lipid Biosynthetic Process
Positive Regulation Of Steroid Metabolic Process
SREBP Signaling Pathway
Cellular Response To Sterol Depletion
Regulation Of Cholesterol Metabolic Process
Response To Sterol Depletion
Proteasome Regulatory Particle, Base Subcomplex
Tagcloud
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