INSIG2 and PSMC5

Number of citations of the paper that reports this interaction (PMID 19815544)
9

Data Source:
BioGRID (pull down)

		INSIG2	PSMC5
Gene Name		insulin induced gene 2	proteasome (prosome, macropain) 26S subunit, ATPase, 5
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle Membrane Inclusion Body Proteasome Accessory Complex Cytoplasmic Vesicle Nuclear Proteasome Complex Cytosolic Proteasome Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding Transcription Factor Binding	Transcription Cofactor Activity Protein Binding ATP Binding Transcription Factor Binding ATPase Activity TBP-class Protein Binding Thyrotropin-releasing Hormone Receptor Binding
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Response To Insulin SREBP Signaling Pathway Inner Ear Morphogenesis Middle Ear Morphogenesis Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Palate Development Cranial Suture Morphogenesis Response To Fatty Acid	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Transcription From RNA Polymerase II Promoter Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Small Molecule Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-Protein Interactions		8 interactors: PSMA7 PSMB1 PSMC3 PSMC5 RNF5 SCAP SREBF2 VCP	36 interactors: CAMK2A EPHA8 ERCC3 ESR1 FOS GTF2B HOMER3 HTT INSIG2 KRT15 KRT38 KRT40 MDM2 MYO18B NR1I2 NR1I3 PARK2 PDC PDCL PLEKHO1 PSMC3 PSMC4 RAD23A RARA RORA RXRA SP1 TAF10 THAP11 THRB TNNT1 TP53 TRIP11 UBE3C USP4 VDR
Entrez ID		51141	5705
HPRD ID		16361	03400
Ensembl ID		ENSG00000125629	ENSG00000087191
Uniprot IDs		B4DQ23 Q9Y5U4	P62195
PDB IDs		4J82	2KRK 3KW6
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Polyubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Ubiquitin-dependent Protein Catabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Modification-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Protein Ubiquitination Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity Protein Modification By Small Protein Conjugation Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Proteolysis Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Cellular Response To Organic Cyclic Compound Hormone-mediated Signaling Pathway Response To Steroid Hormone Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Cellular Response To Lipid Intracellular Receptor Signaling Pathway Regulation Of Metabolic Process Response To Lipid Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Response To Organic Cyclic Compound Transcription, DNA-templated Gene Expression Response To Hormone RNA Biosynthetic Process Viral Process Cellular Response To Hormone Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Response To Organic Substance Regulation Of Gene Expression Cellular Response To Stimulus Nitrogen Compound Metabolic Process Signaling Negative Regulation Of Cellular Metabolic Process Cell Communication Signal Transduction Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Metabolic Process Female Pregnancy Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Tagcloud ?		1alpha ampkalpha anchor atherosclerotic cd36 cholesterol coa coactivator deacetylation escort hexarelin hmg lifted peroxisome pgc pgc1alpha ppargamma ppargamma1 proliferator reductase revealing scap scavenger ser srebp sterol unresponsive	11p11 12q15 17q23 19p13 19q13 20s 26s 7q22 atpases charges consitute machine modules mss1 multisubunit p42 pa700 proteasome psmc1 psmc2 psmc3 psmc4 psmc6 q13 q22 q23 s4 tbp1 tbp7
Tagcloud (Difference) ?		1alpha ampkalpha anchor atherosclerotic cd36 cholesterol coa coactivator deacetylation escort hexarelin hmg lifted peroxisome pgc pgc1alpha ppargamma ppargamma1 proliferator reductase revealing scap scavenger ser srebp sterol unresponsive	11p11 12q15 17q23 19p13 19q13 20s 26s 7q22 atpases charges consitute machine modules mss1 multisubunit p42 pa700 proteasome psmc1 psmc2 psmc3 psmc4 psmc6 q13 q22 q23 s4 tbp1 tbp7
Tagcloud (Intersection) ?