INSIG2 and GPR152

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		INSIG2	GPR152
Description		insulin induced gene 2	G protein-coupled receptor 152
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane SREBP-SCAP-Insig Complex	Plasma Membrane Membrane
	Molecular Function	Protein Binding Oxysterol Binding Lipid Binding Protein Sequestering Activity	G Protein-coupled Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Biosynthetic Process Response To Sterol Depletion Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Response To Insulin Cellular Response To Insulin Stimulus SREBP Signaling Pathway Response To Lipid SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process Protein Maturation Roof Of Mouth Development Cranial Suture Morphogenesis Response To Fatty Acid	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 30275531 24097068) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lumbar spine bone mineral density ( 22504420) Monobrow ( 27182965) Mosquito bite size ( 28199695) Total cholesterol levels ( 30275531)	Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278)
Interacting Genes		55 interacting genes: ABHD4 AQP2 AQP6 ARL13B ATP6V0B BIK CD40 CD79A CPLX4 CREB3L1 CYBC1 EBP ELOVL4 ERGIC3 FAM209A FAM210B GJA8 GOLM1 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LAPTM5 LHFPL5 LMNA MMGT1 MTIF3 MUC1 NEMP1 PCK1 PRLR PSCA PSMA7 PSMB1 PSMC3 PSMC5 PVR RNF5 SCAP SCN3B SLC10A1 SLC16A10 SLC18A1 SLC35H1 SREBF2 STIM1 TMEM14B TMEM237 TMEM45B TMEM52B TMX2 VCP VMA21	197 interacting genes: ABCG4 ABHD16A ACSF2 ADIPOQ AGTRAP AIG1 ANKRD46 APOL3 AQP10 AQP3 AQP6 ARL6IP1 ARV1 ATP6V0C B3GNT7 BDNF BET1 BMP10 BNIP2 BNIP3 C14orf180 C1QL4 C8A CCDC167 CCL4 CCL4L2 CD53 CD72 CD81 CDIPT CDS2 CGRRF1 CLDND2 CLEC17A CLEC1A CLN5 CNIH1 COL8A2 COMT CRISP3 CSGALNACT2 CTXN3 CYB561 CYB561A3 CYB5B CYB5R3 CYBC1 DEFB108B DGAT2L6 EBP EDDM3B EFNA5 EMD ERG28 ERGIC3 FA2H FAM209A FAM20B FAXDC2 FDFT1 FUNDC2 FXYD3 FXYD6-FXYD2 GAST GJB2 GOLT1A GOLT1B GOSR2 GPR151 GPR37L1 HHATL HMOX1 HMOX2 IFNA8 IGF2 IGFBP5 IL1RL1 INS-IGF2 INSIG2 JAGN1 KCNA1 KCNN4 LAMB1 LAT LEPROTL1 LHFPL2 LHFPL5 LTC4S MAL MAL2 MFF MFSD6 MGLL MGST3 MMD MOSPD3 MS4A13 MYADML2 NAT8 NDUFB11 NEU1 NINJ2 NIPAL4 ORMDL1 ORMDL3 PEDS1-UBE2V1 PEX16 PGAP2 PIGF PIN1 PLN PNLIPRP1 PRAF2 PROM2 PTPRN RABAC1 RBFA REEP6 ROBO2 RTN3 RTP2 SACM1L SCAMP4 SCD SEC22B SERF1A SERF1B SERP2 SFT2D2 SFTPC SLC10A1 SLC13A4 SLC29A2 SLC30A3 SLC35A4 SLC35B1 SLC35B4 SLC35F6 SLC35H1 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC61A1 SLC66A1 SLC66A2 SLC7A1 SMCO4 STATH STX1B STX3 STX4 STX5 STX8 SYT15 SYT15B TAP1 TEX264 TFRC THBD THSD7B TIMMDC1 TM4SF19 TMEM100 TMEM120B TMEM128 TMEM140 TMEM14B TMEM14C TMEM201 TMEM208 TMEM218 TMEM236 TMEM237 TMEM243 TMEM254 TMEM42 TMEM50B TMEM54 TMEM60 TMEM97 TMPPE TNFRSF10C TSNARE1 TSPAN33 TSPAN7 TSPO2 UBIAD1 UNC50 VAMP1 VAMP4 VAMP5 VKORC1 YIPF1 YIPF4 YIPF6 ZDHHC15
Entrez ID		51141	390212
HPRD ID		16361	13599
Ensembl ID		ENSG00000125629	ENSG00000175514
Uniprot IDs		B4DQ23 Q9Y5U4	A0A0I9RJ67 Q8TDT2
PDB IDs		4J82 6M49 7ETW
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Proteasome Complex Endoplasmic Reticulum C-8 Sterol Isomerase Activity Positive Regulation Of Cholesterol Biosynthetic Process Cytoplasmic Vesicle Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Proteasome-activating Activity Positive Regulation Of Steroid Biosynthetic Process Protein Binding Renal Water Transport Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process SREBP Signaling Pathway Cellular Response To Sterol Depletion Regulation Of Cholesterol Metabolic Process Response To Sterol Depletion Proteasome Regulatory Particle, Base Subcomplex	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Endomembrane System Golgi Membrane Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Sterol Biosynthetic Process SNARE Binding Vesicle-mediated Transport Membrane Organization Membrane Fusion Lipid Biosynthetic Process Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Transmembrane Transport Cellular Localization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Organization Golgi Apparatus Cholesterol Biosynthetic Process Steroid Biosynthetic Process Membrane Docking Vesicle Docking Cortical Endoplasmic Reticulum Basolateral Plasma Membrane Lipid Metabolic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity Lysine Transport Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Organelle Membrane Cholesterol Binding Nuclear Inner Membrane Organelle Localization By Membrane Tethering SNARE Complex Assembly Trans-Golgi Network Amyloid Fibril Formation Establishment Of Localization In Cell Establishment Of Protein Localization Nitric-oxide Synthase Complex UDP-glucose Transmembrane Transport Golgi Vesicle Transport Amino Acid Transmembrane Transport Water Channel Activity
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