INSIG2 and RNF5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		INSIG2	RNF5
Gene Name		insulin induced gene 2	ring finger protein 5, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Transcription Factor Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Response To Insulin SREBP Signaling Pathway Inner Ear Morphogenesis Middle Ear Morphogenesis Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Palate Development Cranial Suture Morphogenesis Response To Fatty Acid	Response To Bacterium Negative Regulation Of Autophagy Protein Destabilization Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination ER-associated Misfolded Protein Catabolic Process Regulation Of Autophagic Vacuole Assembly
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)	Prostate cancer ( 23535732)
Protein-Protein Interactions		8 interactors: PSMA7 PSMB1 PSMC3 PSMC5 RNF5 SCAP SREBF2 VCP	32 interactors: ABHD16A CFTR CYB561 CYB561A3 FHOD1 INSIG2 JKAMP MAVS MPDZ PXN RNF185 SEC22A SLC1A1 SLC38A7 TGFBR1 TMEM242 TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2K UBE2N UBE2U UBE2V1 UBE2W UBE2Z YIPF2
Entrez ID		51141	6048
HPRD ID		16361	04057
Ensembl ID		ENSG00000125629	ENSG00000204308
Uniprot IDs		B4DQ23 Q9Y5U4	Q99942
PDB IDs		4J82
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Polyubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Ubiquitin-dependent Protein Catabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Modification-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Protein Ubiquitination Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity Protein Modification By Small Protein Conjugation Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Proteolysis Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Activation Of Innate Immune Response Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Positive Regulation Of Innate Immune Response Cellular Protein Modification Process Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Protein Metabolic Process Cellular Response To Stress Toll-like Receptor Signaling Pathway Proteolysis Immune Response-regulating Signaling Pathway Protein Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Ubiquitination Catabolic Process Positive Regulation Of Immune Response Histone Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Monoubiquitination Response To Organic Substance Negative Regulation Of Type I Interferon Production ISG15-protein Conjugation Aspartate Transport Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Innate Immune Response Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune Response Cellular Response To Transforming Growth Factor Beta Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		1alpha ampkalpha anchor atherosclerotic cd36 cholesterol coa coactivator deacetylation escort hexarelin hmg lifted peroxisome pgc pgc1alpha ppargamma ppargamma1 proliferator reductase revealing scap scavenger ser srebp sterol unresponsive	adapt autoadaptive built cleared clients deploys dislocation dislocon dislocons engage erad folding herp hrd1 interrupt ligases machineries misfolded p97 perturbation polyubiquitylation preempt proteasomal proteostasis relay relies tuning turnover ubc6e
Tagcloud (Difference) ?		1alpha ampkalpha anchor atherosclerotic cd36 cholesterol coa coactivator deacetylation escort hexarelin hmg lifted peroxisome pgc pgc1alpha ppargamma ppargamma1 proliferator reductase revealing scap scavenger ser srebp sterol unresponsive	adapt autoadaptive built cleared clients deploys dislocation dislocon dislocons engage erad folding herp hrd1 interrupt ligases machineries misfolded p97 perturbation polyubiquitylation preempt proteasomal proteostasis relay relies tuning turnover ubc6e
Tagcloud (Intersection) ?