RPIA and CENPP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		RPIA	CENPP
Description		ribose 5-phosphate isomerase A	centromere protein P
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Chromosome, Centromeric Region Inner Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol
	Molecular Function	Ribose-5-phosphate Isomerase Activity Protein Binding Isomerase Activity Carbohydrate Binding Identical Protein Binding Monosaccharide Binding	Protein Binding
	Biological Process	D-ribose Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch	Chromosome Segregation CENP-A Containing Chromatin Assembly
Pathways		RPIA deficiency: failed conversion of R5P to RU5P RPIA deficiency: failed conversion of RU5P to R5P Pentose phosphate pathway	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		4-phospho-L-threonic acid
Diseases
GWAS		Blood protein levels ( 30072576)	End-stage renal disease ( 29885931) HDL cholesterol levels ( 32203549) Height ( 28552196 31562340) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Urate levels ( 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		20 interacting genes: ATPAF2 C14orf119 CENPP DDIT4L FOXP2 FXR1 FXR2 GORASP2 HSPB8 LNX1 NIF3L1 NTAQ1 PCMT1 PICK1 PTPN11 RNF208 SDCBP STK16 TXN2 VTA1	26 interacting genes: AKAP19 ATP6V0D2 BACH2 CCDC33 CCDC85B CEP44 GOLGA2 HAUS1 KIAA1328 KLC3 LMNA MBD3 NHLH1 NTAQ1 PKNOX2 POLR3K RNF126 RPIA SERTAD3 STXBP1 SYCE1L TEX11 TOX2 USHBP1 ZNF341 ZNF765
Entrez ID		22934	401541
HPRD ID		01589	17989
Ensembl ID		ENSG00000153574	ENSG00000188312
Uniprot IDs		P49247	Q6IPU0
PDB IDs			7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Translation Regulator Activity Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity	Centrosome Cycle
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