RPIA and HSPB8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RPIA	HSPB8
Description		ribose 5-phosphate isomerase A	heat shock protein family B (small) member 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Protein Folding Chaperone Complex
	Molecular Function	Ribose-5-phosphate Isomerase Activity Protein Binding Isomerase Activity Carbohydrate Binding Identical Protein Binding Monosaccharide Binding	Protein Kinase Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	D-ribose Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch	Cellular Response To Unfolded Protein Positive Regulation Of Aggrephagy
Pathways		RPIA deficiency: failed conversion of R5P to RU5P RPIA deficiency: failed conversion of RU5P to R5P Pentose phosphate pathway	HSF1-dependent transactivation
Drugs		4-phospho-L-threonic acid
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS		Blood protein levels ( 30072576)	Metabolite levels ( 23823483) PR interval in Tripanosoma cruzi seropositivity ( 24324551)
Interacting Genes		20 interacting genes: ATPAF2 C14orf119 CENPP DDIT4L FOXP2 FXR1 FXR2 GORASP2 HSPB8 LNX1 NIF3L1 NTAQ1 PCMT1 PICK1 PTPN11 RNF208 SDCBP STK16 TXN2 VTA1	21 interacting genes: ATOSB ATXN7L2 BAG3 CATSPERT CRYAB CSNK2A1 DUSP12 HSPB1 HSPB2 HSPB3 HSPB6 HSPB7 MAPK3 MISP PRKCA QRICH1 RPIA SLC16A5 SNCA SOCS7 TRAPPC6A
Entrez ID		22934	26353
HPRD ID		01589	06420
Ensembl ID		ENSG00000153574	ENSG00000152137
Uniprot IDs		P49247	Q9UJY1
PDB IDs			8S7A
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Translation Regulator Activity Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity	Response To Unfolded Protein Protein Refolding Response To Heat Protein Folding Response To Temperature Stimulus Structural Constituent Of Eye Lens Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Unfolded Protein Binding Positive Regulation Of Aggrephagy Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Protein Stability Regulation Of Autophagy Response To Stress Contractile Muscle Fiber Protein Transport Along Microtubule Protein Stabilization Positive Regulation Of Macroautophagy Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Protein Catabolic Process Apoptotic Process Z Disc Negative Regulation Of Protein Metabolic Process Cell Death Programmed Cell Death Aggresome Negative Regulation Of Striated Muscle Cell Apoptotic Process Cytoplasm Positive Regulation Of Autophagy Positive Regulation Of Angiogenesis Negative Regulation Of Protein Kinase C Signaling Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ribose-5-phosphate Isomerase Activity Positive Regulation Of Vasculature Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Regulation Of Macroautophagy Response To Mechanical Stimulus
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