MAPRE1 and KIF2C

Number of citations of the paper that reports this interaction (PMID 23001180)
7

Data Source:
BioGRID (pull down)

		MAPRE1	KIF2C
Gene Name		microtubule-associated protein, RP/EB family, member 1	kinesin family member 2C
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Microtubule Cytoplasmic Microtubule Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Nucleus Cytosol Kinesin Complex Cytoplasmic Microtubule Microtubule Cytoskeleton Membrane Microtubule Plus-end
	Molecular Function	Protein Binding Protein C-terminus Binding Poly(A) RNA Binding Microtubule Plus-end Binding	Microtubule Motor Activity Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Microtubule Plus-end Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Cell Proliferation Negative Regulation Of Microtubule Polymerization Protein Localization To Microtubule Cell Division Positive Regulation Of Microtubule Plus-end Binding	Mitotic Cell Cycle Microtubule-based Movement Microtubule Depolymerization Mitotic Nuclear Division Mitotic Metaphase Plate Congression Blood Coagulation Metabolic Process Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Cell Division Regulation Of Chromosome Segregation
Pathways		Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes	Mitotic Prometaphase Separation of Sister Chromatids Kinesins Mitotic Anaphase Factors involved in megakaryocyte development and platelet production M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion MHC class II antigen presentation Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: ABCB1 APC APC2 APP AURKB BCL3 CDK5RAP2 CLASP1 CLASP2 CLIP1 COPS5 COPS8 CSN3 CYLD DCTN1 HSPA1A IKBKG KAT2B KAT5 KIF2C LMO2 LRP1 MACF1 MAPRE2 MAPRE3 NAV1 NUPR1 PDE4DIP PIK3R4 POLE2 PQBP1 PSMA1 SPDYE2 STK11 TERF1 TRAF2 TRIO TROAP TUBA1A TUBB	8 interactors: APP AURKA CENPH CSNK2B HIST3H3 MAPRE1 VHL ZNF566
Entrez ID		22919	11004
HPRD ID		04379	05172
Ensembl ID		ENSG00000101367	ENSG00000142945
Uniprot IDs		B4DM33 Q15691	B7Z6Q6 Q99661
PDB IDs		1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3TQ7	2HEH
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Regulation Of Microtubule-based Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Microtubule-based Process Response To Stimulus Organelle Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Complex Assembly Regulation Of Cytoskeleton Organization Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Microtubule Depolymerization Regulation Of Chromosome Segregation Cullin Deneddylation Cellular Localization Regulation Of Wnt Signaling Pathway Establishment Or Maintenance Of Cell Polarity Response To Radiation Protein Deneddylation Negative Regulation Of Microtubule Polymerization Or Depolymerization Cellular Component Assembly Spindle Checkpoint Positive Regulation Of Microtubule Polymerization Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Microtubule Bundle Formation Response To Light Stimulus Cellular Protein Complex Assembly Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Transferase Activity	Regulation Of Binding Regulation Of Protein Binding Protein Localization To Cytoskeleton Mitotic Cell Cycle Negative Regulation Of Microtubule Polymerization Or Depolymerization Cell Morphogenesis Regulation Of Microtubule Polymerization Or Depolymerization Developmental Cell Growth Negative Regulation Of Spindle Checkpoint Posttranscriptional Regulation Of Gene Expression Cell Cycle Spindle Assembly Involved In Female Meiosis I Synaptic Growth At Neuromuscular Junction Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Stability Developmental Growth Involved In Morphogenesis Neuron Projection Morphogenesis Spindle Assembly Involved In Meiosis Collateral Sprouting In Absence Of Injury Positive Regulation Of Microtubule Plus-end Binding Regulation Of Microtubule Cytoskeleton Organization Cell Growth Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Spindle Stabilization Regulation Of Microtubule-based Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Projection Development Cellular Component Assembly Cell Projection Morphogenesis Axon Choice Point Recognition Cell Part Morphogenesis Positive Regulation Of Cell Cycle Process Positive Regulation Of Oocyte Maturation Positive Regulation Of Activin Receptor Signaling Pathway Protein Localization To Microtubule Adiponectin-activated Signaling Pathway Meiotic Spindle Organization Protein Localization To Centrosome Neuron Remodeling Mitotic Centrosome Separation Neuron Development Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Female Meiosis I Developmental Growth Positive Regulation Of Oocyte Development
Tagcloud ?		akap450 akap9 disrupting eb1 endoplasmic fragmentation functioned golgi immunoprecipitation interacting isoform microtubule microtubules mmg8 myomegalin networks newly nucleation obscure organization organizing participates predominantly reticulum thereby tracking trafficking tubulin variant	acquisition bioinformatics blocking catastrophe chemoresistance chemoresistant chemosensitive chip clinicopathological contributes deregulation documented establish foxm1 immunohistochemistry implicated invasion knockdown migration mitotic multivariate ovarian paclitaxel prognostic qpcr shorter silencing targets tumorigenesis
Tagcloud (Difference) ?		akap450 akap9 disrupting eb1 endoplasmic fragmentation functioned golgi immunoprecipitation interacting isoform microtubule microtubules mmg8 myomegalin networks newly nucleation obscure organization organizing participates predominantly reticulum thereby tracking trafficking tubulin variant	acquisition bioinformatics blocking catastrophe chemoresistance chemoresistant chemosensitive chip clinicopathological contributes deregulation documented establish foxm1 immunohistochemistry implicated invasion knockdown migration mitotic multivariate ovarian paclitaxel prognostic qpcr shorter silencing targets tumorigenesis
Tagcloud (Intersection) ?